N-叔丁氧羰基-去甲托品酮合成路线 （共 29 条）
参考文献
Gong, Leyi; Hogg, J. Heather; Collier, James; Wilhelm, Robert S.; Soderberg, Carol
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3597 - 3600
反应条件
hydrogen; palladium hydroxide on carbon in ethyl acetate P=3102.97 Torr;
参考文献
US2006/100426 A1, ;
Page/Page column 18 ;
US 20060100426 A1
反应条件
N-ethyl-N,N-diisopropylamine in 1,4-dioxane; water T=20°C; 3 h;
参考文献
Roche Palo Alto LLC
Patent: US2009/318493 A1, 2009 ;
Location in patent: Page/Page column 41-42 ;
US 20090318493 A1
反应条件
hydrogen; palladium dihydroxide in di-tert-butyl dicarbonate; ethyl acetate
参考文献
Pfizer Inc.
Patent: US2002/119961 A1, 2002 ;
反应条件
1: 8-methyl-8-aza-bicyclo[3.2.1]octan-3-one With 1-chloroethyl chlorocarbonate in 1,2-dichloro-ethane T=80°C; 5 h; 2: With methanol T=75°C; 1.5 h; 3: di-tert-butyl dicarbonate With sodium hydroxide in water T=20°C;
参考文献
Bezencon, Olivier; Bur, Daniel; Corminboeuf, Olivier; Dube, Daniel; Grisostomi, Corinna; MacDonald, Dwight; McKay, Dan; Powell, David; Remen, Lubos; Richard-Bildstein, Sylvia; Scheigetz, John; Therien, Michel; Weller, Thomas
Patent: US2009/176823 A1, 2009 ;
Location in patent: Page/Page column 28 ;
反应条件
1: 1-chloroethyl chlorocarbonate; 8-methyl-8-aza-bicyclo[3.2.1]octan-3-one in 1,2-dichloro-ethane T=80°C; 5 h; 2: With methanol T=20 - 75°C; 1.5 h; 3: di-tert-butyl dicarbonate With sodium hydroxide more than 3 stages;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2007/88514 A1, 2007 ;
Location in patent: Page/Page column 75-76 ;
WO 2007/088514 A1
反应条件
1: 8-(phenylmethyl)-8-azabicyclo[3.2.1]octan-3-one With ammonium formate; 30 Pd/C in ethanol 4 h; Heating / reflux; 2: di-tert-butyl dicarbonate in tetrahydrofuran; water T=20°C; 18 h;
参考文献
US2007/167442 A1, ;
Page/Page column 45 ;
反应条件
1.1: 1-chloroethyl chloroformate / 1,2-dichloro-ethane / 80 °C 1.2: MeOH / 1,2-dichloro-ethane / 50 °C 2.1: aq. NaOH / propan-2-ol / 23 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 21 p. 5281 - 5284
反应条件
triethylamine in methanol 0.5 h; Reflux;
参考文献
Journal of Medicinal Chemistry, , vol. 51, # 19 p. 6095 - 6109
反应条件
1.1: tetrahydrofuran / 0.33 h / -60 - -20 °C 1.2: 0.33 h / -20 °C 2.1: [Fe(II)(C5H5)(C5H4PPh2)] / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / 1,4-dioxane / 1 h / 85 °C View Scheme
参考文献
SCHERING CORPORATION; MENG, Zhaoyang; REDDY, Panduranga Adulla, P.; SIDDIQUI, M. Arshad; MANDAL, Amit, K.; LIU, Duan; ZHAO, Lianyun; MCRINER, Andrew
Patent: WO2012/27234 A1, 2012 ;
WO 2012/027234 A1
