(8R,9S,10R,13S,14S)-10,13-二甲基螺[7,8,9,11,12,13,15,16-八氢-6H-环戊并[a]菲-6,2-环氧乙烷]-3,17(10H,14H)-二酮合成路线 （共 3 条）
→
184972-12-1(8R,9S,10R,13S,14S)-10,13-二甲基螺[7,8,9,11,12,13,15,16-八氢-6H-环戊并[a]菲-6,2-环氧乙烷]-3,17(10H,14H)-二酮
反应条件
3-chloro-benzenecarboperoxoic acid in dichloromethane 48 h; Ambient temperature;
参考文献
Buzzetti; Di Salle; Longo; Briatico
Steroids, 1993 , vol. 58, # 11 p. 527 - 532
→
184972-12-1(8R,9S,10R,13S,14S)-10,13-二甲基螺[7,8,9,11,12,13,15,16-八氢-6H-环戊并[a]菲-6,2-环氧乙烷]-3,17(10H,14H)-二酮
反应条件
1: 1.) Me2NH*HCl / 1.) isoamyl alcohol, reflux, 2 h, 2.) isoamyl alcohol, reflux, 15 h 2: 85 percent / Jones reagent / acetone / 0.25 h / -20 °C 3: 80 percent / 50percent m-chloroperbenzoic acid / CH2Cl2 / 48 h / Ambient temperature View Scheme
参考文献
Steroids, , vol. 58, # 11 p. 527 - 532
→
184972-12-1(8R,9S,10R,13S,14S)-10,13-二甲基螺[7,8,9,11,12,13,15,16-八氢-6H-环戊并[a]菲-6,2-环氧乙烷]-3,17(10H,14H)-二酮
反应条件
1: 85 percent / Jones reagent / acetone / 0.25 h / -20 °C 2: 80 percent / 50percent m-chloroperbenzoic acid / CH2Cl2 / 48 h / Ambient temperature View Scheme
参考文献
Steroids, , vol. 58, # 11 p. 527 - 532
