1-苯基-4-己炔-3-醇合成路线 （共 6 条）
反应条件
1: With n-butyllithium; propenyl bromide in tetrahydrofuran; diethyl ether T=-78°C; 0.666667 h; Inert atmosphere; 2: With ammonium chloride in tetrahydrofuran; diethyl ether; water
参考文献
Takahashi, Masayuki; McLaughlin, Martin; Micalizio, Glenn C.
Angewandte Chemie, International Edition, 2009 , vol. 48, # 20 p. 3648 - 3652
反应条件
in tetrahydrofuran T=0 - 20°C; Grignard reaction; Inert atmosphere;
参考文献
Akai, Shuji; Hanada, Ryosuke; Fujiwara, Noboru; Kita, Yasuyuki; Egi, Masahiro
Organic Letters, 2010 , vol. 12, # 21 p. 4900 - 4903
反应条件
1: 5-phenyl-1-pentyn-3-ol With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; 2: methyl iodide With N,N,N',N',N'',N''-hexamethylphosphoric triamide in tetrahydrofuran; hexane T=-78 - 20°C;
参考文献
Kiyotsuka, Yohei; Kobayashi, Yuichi
Journal of Organic Chemistry, 2009 , vol. 74, # 19 p. 7489 - 7495
反应条件
n-butyllithium 1.) THF, hexane, RT, 4 h, 2.) THF, 0 deg C, 0.5 h; Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 51, # 21 p. 4006 - 4016
反应条件
diethyl ether; ammonia
参考文献
Journal of the Chemical Society, , p. 1874,1877
反应条件
Celite; pyridinium chlorochromate in dichloromethane T=20°C; Cooling with ice;
参考文献
Kiyotsuka, Yohei; Kobayashi, Yuichi
Journal of Organic Chemistry, 2009 , vol. 74, # 19 p. 7489 - 7495
