1-甲基吲哚-2-羧酸乙酯合成路线 （共 25 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=30°C; 36 h;
参考文献
Chen, Wenyong; Sana, Kasinath; Jiang, Yi; Meyer, Esmerelda V. S.; Lapp, Stacey; Galinski, Mary R.; Liebeskind, Lanny S.
Organometallics, 2013 , vol. 32, # 24 p. 7594 - 7611
反应条件
1: LAH / tetrahydrofuran 2: NaH / dimethylformamide / 80 °C View Scheme
参考文献
Faul, Margaret M.; Winneroski, Leonard L.
Tetrahedron Letters, 1997 , vol. 38, # 27 p. 4749 - 4752
反应条件
1: diisobutylaluminium hydride / tetrahydrofuran; hexane / 0.5 h / -78 °C / |Inert atmosphere 2: manganese(IV) oxide / acetonitrile / 20 °C / |Inert atmosphere View Scheme
参考文献
Chen, Wenyong; Sana, Kasinath; Jiang, Yi; Meyer, Esmerelda V. S.; Lapp, Stacey; Galinski, Mary R.; Liebeskind, Lanny S.
Organometallics, 2013 , vol. 32, # 24 p. 7594 - 7611
参考文献
Kali-Chemie Pharma GmbH
Patent: US4965369 A1, 1990 ;
反应条件
1: 86 percent / aq. KOH / ethanol / 0.5 h / Heating 2: SOCl2 / dioxane / 25 - 30 °C View Scheme
参考文献
Font, M.; Monge, A.; Cuartero, A.; Ellorriaga, A.; Martinez-Irujo, J.J.; et al.
European Journal of Medicinal Chemistry, 1995 , vol. 30, # 12 p. 963 - 972
反应条件
potassium hydroxide in ethanol 0.5 h; Heating;
参考文献
Font, M.; Monge, A.; Cuartero, A.; Ellorriaga, A.; Martinez-Irujo, J.J.; et al.
European Journal of Medicinal Chemistry, 1995 , vol. 30, # 12 p. 963 - 972
反应条件
1: ethyl 1H-indole-2-carboxylate With sodium hydride in DMF (N,N-dimethyl-formamide)
0.333333 - 0.416667 h;
2: methyl iodide in DMF (N,N-dimethyl-formamide)
T=40 - 45°C; 1 h;
参考文献
Affinium Pharmaceuticals, Inc.
Patent: US6762201 B1, 2004 ;
Location in patent: Page/Page column 12 ;
反应条件
potassium carbonate in acetonitrile
T=90°C; 6 h;
参考文献
GRUeNENTHAL GMBH; FRANK, Robert; CHRISTOPH, Thomas; LESCH, Bernhard; LEE, Jeewoo
Patent: WO2012/62462 A1, 2012 ;
Location in patent: Page/Page column 77 ;
反应条件
1: ethyl 1H-indole-2-carboxylate With sodium hydride in tetrahydrofuran; mineral oil
T=0 - 20°C; 1 h; Inert atmosphere;
2: methy halide T=0 - 20°C; 24 h;
参考文献
Fraile, Jose M.; Le Jeune, Karel; Mayoral, Jose A.; Ravasio, Nicoletta; Zaccheria, Federica
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 26 p. 4327 - 4332
反应条件
hydrogenchloride; ethanol
参考文献
Johnson et al.
Journal of the American Chemical Society, 1945 , vol. 67, p. 423,428
Journal of the American Chemical Society, 1947 , vol. 69, p. 2370
