(4R)-N-乙酰基)-4-苯基-2-唑烷酮合成路线 （共 6 条）
反应条件
1: (R)-4-(phenylmethyl)-2-oxazolidinone With n-butyllithium in tetrahydrofuran; hexane T=-40°C; 0.25 h; Inert atmosphere; 2: acetyl chloride in tetrahydrofuran; hexane T=-40°C; 1 h; Inert atmosphere;
参考文献
Thorn, Karina; Nielsen, Carsten Uhd; Jakobsen, Palle; Steffansen, Bente; Zercher, Charles K.; Begtrup, Mikael
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 15 p. 4597 - 4601
反应条件
1H-1,2,4-triazol; 1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile T=20°C; 10 h;
参考文献
Yang, Xing; Birman, Vladimir B.
Organic Letters, 2009 , vol. 11, # 7 p. 1499 - 1502
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in tetrahydrofuran 1 h; Ambient temperature;
参考文献
Ager, David J.; Allen, David R.; Schaad, David R.
Synthesis, 1996 , # 11 p. 1283 - 1285
参考文献
Abbott Laboratories
Patent: US6133275 A1, 2000 ;
反应条件
1.1: triethylamine / dichloromethane / 2 h / 10 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -40 °C / Inert atmosphere 2.2: 1 h / -40 °C / Inert atmosphere View Scheme
参考文献
Thorn, Karina; Nielsen, Carsten Uhd; Jakobsen, Palle; Steffansen, Bente; Zercher, Charles K.; Begtrup, Mikael
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 15 p. 4597 - 4601
反应条件
1.1: boron trifluoride diethyl etherate / tetrahydrofuran / 0.08 h / Reflux 1.2: Reflux 2.1: triethylamine / dichloromethane / 2 h / 10 °C 3.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -40 °C / Inert atmosphere 3.2: 1 h / -40 °C / Inert atmosphere View Scheme
参考文献
Thorn, Karina; Nielsen, Carsten Uhd; Jakobsen, Palle; Steffansen, Bente; Zercher, Charles K.; Begtrup, Mikael
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 15 p. 4597 - 4601
