3-羟基-2,2-二甲基丙基氨基甲酸叔丁酯合成路线 （共 6 条）
反应条件
in dichloromethane T=20°C; 16 h;
参考文献
Nagata, Naoya; Furuya, Kazuyuki; Oguro, Nao; Nishiyama, Daisuke; Kawai, Kentaro; Yamamoto, Noriko; Ohyabu, Yuki; Satsukawa, Masahiro; Miyakawa, Motonori
ChemMedChem, 2014 , vol. 9, # 1 p. 197 - 206
反应条件
1.1: 83 percent / PPh3; DIAD / tetrahydrofuran / 20 °C 2.1: Mg; MeOH / 0.5 h / 20 °C / sonication 3.1: n-BuLi / diethyl ether / 0 - 20 °C 3.2: diethyl ether / 1 h / 20 °C 4.1: AIBN; n-Bu3SnH / toluene / 0.5 h / -10 °C / Irradiation 4.2: 43 mg / aq. H2O2; KF; KHCO3 / tetrahydrofuran; methanol / 20 h / 20 °C View Scheme
参考文献
Organic letters, , vol. 5, # 8 p. 1341 - 1344
反应条件
1.1: n-BuLi / diethyl ether / 0 - 20 °C 1.2: diethyl ether / 1 h / 20 °C 2.1: AIBN; n-Bu3SnH / toluene / 0.5 h / -10 °C / Irradiation 2.2: 43 mg / aq. H2O2; KF; KHCO3 / tetrahydrofuran; methanol / 20 h / 20 °C View Scheme
参考文献
Organic letters, , vol. 5, # 8 p. 1341 - 1344
反应条件
1.1: Mg; MeOH / 0.5 h / 20 °C / sonication 2.1: n-BuLi / diethyl ether / 0 - 20 °C 2.2: diethyl ether / 1 h / 20 °C 3.1: AIBN; n-Bu3SnH / toluene / 0.5 h / -10 °C / Irradiation 3.2: 43 mg / aq. H2O2; KF; KHCO3 / tetrahydrofuran; methanol / 20 h / 20 °C View Scheme
参考文献
Organic letters, , vol. 5, # 8 p. 1341 - 1344
反应条件
1: With ruthenium trichloride; sodium periodate in tetrachloromethane; water; acetonitrile T=20°C; 2: With hydrogenchloride in water
参考文献
Kissei Pharmaceutical Co., Ltd.
Patent: EP1548024 A1, 2005 ;
Location in patent: Page/Page column 89-90 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 22 h; Reflux; 2: With water; sodium hydroxide in tetrahydrofuran; diethyl ether T=0 - 20°C; 6 h;
参考文献
CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO); MCNEENEY, Stephen, Phillip; PASTOR FERNÁNDEZ, Joaquín; MARTÍNEZ GONZÁLES, Sonia; MARTÍN HERNANDO, José Ignacio; RODRÍGUEZ HERGUETA, Antonio; RICO FERREIRA, María del Rosario; BLANCO APARICIO, Carmen
Patent: WO2013/4984 A1, 2013 ;
Location in patent: Page/Page column 67 ;
