1.1: diisobutylaluminium hydride / toluene / 12 h / 20 °C 2.1: triethylamine / dichloromethane / 1 h / 0 °C 3.1: 2,4,6-trimethyl-pyridine; water / acetone / 3 h / 60 °C 4.1: N-ethyl-N,N-diisopropylamine; (1,2-dibromo-1-phenyl-ethyl)-phosphonic acid / dichloromethane / 24 h / 20 °C 4.2: 24 h / 20 °C View Scheme

1.1: diisobutylaluminium hydride / toluene / 12 h / 20 °C 2.1: triethylamine / dichloromethane / 1 h / 0 °C 3.1: 2,4,6-trimethyl-pyridine; water / acetone / 3 h / 60 °C 4.1: N-ethyl-N,N-diisopropylamine; (1,2-dibromo-1-phenyl-ethyl)-phosphonic acid / dichloromethane / 24 h / 20 °C 4.2: 24 h / 20 °C 5.1: Streptomyces coelicolor A3(2) 2-methylisoborneol synthase; magnesium chloride; sodium chloride; 2-hydroxyethanethiol / aq. buffer / 12 h / 30 °C / pH 7 / |Enzymatic reaction View Scheme

1: lithium aluminium tetrahydride 2: bis(acetylacetonate)oxovanadium; tert.-butylhydroperoxide / dichloromethane; decane / 0.58 h / 20 °C 3: triethylamine / dichloromethane / -20 °C 4: ammonia; sodium / diethyl ether / 1 h / -78 - -40 °C View Scheme