(S)-5-苯基-1-戊炔-3-醇合成路线 （共 2 条）
反应条件
<b>Multi-step reaction with 4 steps<br /> </b>1.1: AlMe<sub>3</sub> / toluene / -5 - 0 °C<br />1.2: 82 percent / toluene / 0 - 20 °C<br />2.1: n-BuLi / hexane; tetrahydrofuran / 0.33 h / -78 - 0 °C<br />2.2: 97 percent / tetrahydrofuran; hexane / 2.5 h / -78 - -10 °C<br />3.1: 100 percent / 2-propanol; (S,S)-Noyri's catalyst / 0.33 h<br />4.1: 89.6 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.75 h / 20 °C<br /> <br />
参考文献
Trost, Barry M.; Machacek, Michelle R.; Faulk, Brian D. Journal of the American Chemical Society, 2006 , vol. 128, # 20 p. 6745 - 6754
反应条件
<b>Multi-step reaction with 3 steps<br /> </b>1.1: n-BuLi / hexane; tetrahydrofuran / 0.33 h / -78 - 0 °C<br />1.2: 97 percent / tetrahydrofuran; hexane / 2.5 h / -78 - -10 °C<br />2.1: 100 percent / 2-propanol; (S,S)-Noyri's catalyst / 0.33 h<br />3.1: 89.6 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.75 h / 20 °C<br /> <br />
参考文献
Trost, Barry M.; Machacek, Michelle R.; Faulk, Brian D. Journal of the American Chemical Society, 2006 , vol. 128, # 20 p. 6745 - 6754
