N-BOC-4-氨基-4-羧酸哌啶合成路线 （共 17 条）
反应条件
sodium hydroxide in ethylene glycol dimethyl ether T=20°C; 48 h;
参考文献
Kiviranta, Paeivi H.; Leppaenen, Jukka; Rinne, Valtteri M.; Suuronen, Tiina; Kyrylenko, Olga; Kyrylenko, Sergiy; Kuusisto, Erkki; Tervo, Anu J.; Jaervinen, Tomi; Salminen, Antero; Poso, Antti; Wallen, Erik A.A.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 9 p. 2448 - 2451
反应条件
1: 86 percent / Et3N; DMAP / 1,2-dimethoxy-ethane / 20 °C 2: 76 percent / aq. NaOH / 1,2-dimethoxy-ethane / 48 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 9 p. 2448 - 2451
反应条件
1: 86 percent / Et3N; DMAP / 1,2-dimethoxy-ethane / 20 °C 2: 76 percent / aq. NaOH / 1,2-dimethoxy-ethane / 48 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 9 p. 2448 - 2451
反应条件
1: Et3N, DMAP 3: DMAP / tetrahydrofuran 4: aq. NaOH / 1,2-dimethoxy-ethane / 26 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 22 p. 7650 - 7651
反应条件
2: DMAP / tetrahydrofuran 3: aq. NaOH / 1,2-dimethoxy-ethane / 26 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 22 p. 7650 - 7651
反应条件
1: DMAP / tetrahydrofuran 2: aq. NaOH / 1,2-dimethoxy-ethane / 26 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 22 p. 7650 - 7651
反应条件
1: 75 percent / methanol; H2O / 72 h / 20 °C 2: 86 percent / Et3N; DMAP / 1,2-dimethoxy-ethane / 20 °C 3: 76 percent / aq. NaOH / 1,2-dimethoxy-ethane / 48 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 9 p. 2448 - 2451
反应条件
1: ethanol; H2O / 18 h / 80 °C / 2660 Torr 2: DMAP; Et3N / 1,2-dimethoxy-ethane / 18 h / 20 °C 3: 1 N NaOH / 1,2-dimethoxy-ethane / 20 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 18 p. 2519 - 2522
反应条件
N-ethyl-N,N-diisopropylamine in methanol; hexane; acetonitrile
参考文献
SMITHKLINE BEECHAM PLC
Patent: EP1214314 B1, 2005 ;
Location in patent: Page/Page column 17 ;
反应条件
in methanol; dichloromethane T=20°C; 0.5 h;
参考文献
LG LIFE SCIENCES LTD.; YAMANOUCHI PHARMACEUTICAL CO., LTD.
Patent: WO2005/47253 A1, 2005 ;
Location in patent: Page/Page column 49 ;
WO 2005/047253 A1
