1-t-叔丁氧羰基-哌啶-4-螺-5’-[1’,3’-二-t-叔丁氧羰基]海因合成路线 （共 12 条）
反应条件
4-(N,N-dimethlyamino)pyridine in tetrahydrofuran T=20°C; 18 h;
参考文献
ILDONG PHARMACEUTICAL CO., LTD.
Patent: US2010/168421 A1, 2010 ;
Location in patent: Page/Page column 7 ;
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in ethylene glycol dimethyl ether 21 h; Ambient temperature;
参考文献
Wysong, Christopher L.; Yokum, T. Scott; Morales, Guillermo A.; Gundry, Rebekah L.; McLaughlin, Mark L.; Hammer, Robert P.
Journal of Organic Chemistry, 1996 , vol. 61, # 22 p. 7650 - 7651
反应条件
1: Et3N, DMAP 3: DMAP / tetrahydrofuran View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 22 p. 7650 - 7651
反应条件
1: Et3N, DMAP 3: DMAP / tetrahydrofuran View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 22 p. 7650 - 7651
反应条件
2: DMAP / tetrahydrofuran View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 22 p. 7650 - 7651
反应条件
1: 75 percent / methanol; H2O / 72 h / 20 °C 2: 86 percent / Et3N; DMAP / 1,2-dimethoxy-ethane / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 9 p. 2448 - 2451
反应条件
1: ethanol; H2O / 18 h / 80 °C / 2660 Torr 2: DMAP; Et3N / 1,2-dimethoxy-ethane / 18 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 18 p. 2519 - 2522
反应条件
1: aq. NaOH / 1,2-dimethoxy-ethane / 26 h 2: H2O; 1,2-dimethoxy-ethane / 18 h / Ambient temperature; pH 9.0-9.5 View Scheme
参考文献
Wysong, Christopher L.; Yokum, T. Scott; Morales, Guillermo A.; Gundry, Rebekah L.; McLaughlin, Mark L.; Hammer, Robert P.
Journal of Organic Chemistry, 1996 , vol. 61, # 22 p. 7650 - 7651
反应条件
sodium hydroxide in ethylene glycol dimethyl ether T=20°C; 48 h;
参考文献
Kiviranta, Paeivi H.; Leppaenen, Jukka; Rinne, Valtteri M.; Suuronen, Tiina; Kyrylenko, Olga; Kyrylenko, Sergiy; Kuusisto, Erkki; Tervo, Anu J.; Jaervinen, Tomi; Salminen, Antero; Poso, Antti; Wallen, Erik A.A.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 9 p. 2448 - 2451
反应条件
1: With sodium hydroxide; water in tetrahydrofuran T=0 - 20°C; 24 h; 2: With hydrogenchloride; water pH=2.5;
参考文献
ILDONG PHARMACEUTICAL CO., LTD.
Patent: US2010/168421 A1, 2010 ;
Location in patent: Page/Page column 7 ;
