carbon monoxide in tetrahydrofuran High Pressure; 0.05 mmol Pd compound, 0.1 mmol EtCu, 2,5 ml THF, CO 30 atm (at -50°C), stirred for 2 h at 25°C in presence of 0.1 mmol MgBrI (yield of PhCEt(OH)COEt/PhCOCEt2(OH): 17percent); GC-MS, GC;

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carbon monoxide in tetrahydrofuran High Pressure; 0.05 mmol Pd compound, 0.1 mmol EtCu, 2,5 ml THF, CO 30 atm (at -50°C), stirred for 2 h at 25°C in presence of 0.1 mmol MgBrI (yield of PhCEt(OH)COEt/PhCOCEt2(OH): 17percent); GC-MS, GC;

lithium bromide in tetrahydrofuran a soln. of dry LiBr in THF was added at 20°C under N2 to a stirred suspn. of CuBr in THF, soln. was cooled to -60°C and a soln. of EtMgCl in THF was added dropwise, mixt. was stirred for 15 min at -60°C; not isolated from the soln., used directly for further reactions;

copper(l) iodide; diethyl ether

carbon monoxide in tetrahydrofuran High Pressure; 0.05 mmol Pd compound, 0.1 mmol EtCu, 2,5 ml THF, CO 30 atm (at -50°C), stirred for 2 h at 25°C in presence of 0.1 mmol MgBrI (yield of PhCEt(OH)COEt/PhCOCEt2(OH): 17percent); GC-MS, GC;

in tetrahydrofuran propargylic chloride was added under N2 at -60°C to a soln. of EtCu in THF, mixt. was stirred for 1 h at -60°C; purity of the product >=95percent; mixt. was poured into satd. aq. NH4Cl containing NaCN, extd. with 1:1 ether-pentane, combined exts. were washed with water, dried over MgSO4, solvent was evapd. in vacuo, residue crystd. from methanol or purified by column chromy. (Al2O3, hexane);

(i) EtLi, (ii) /BRN= 605308/; Multistep reaction;

(i) dioxane, Et2O, (ii) /BRN= 3660023/, (iii) /BRN= 1900390/; Multistep reaction;

(i) dioxane, Et2O, (ii) /BRN= 3660023/, (iii) /BRN= 1900390/; Multistep reaction;