4-苄氧基-3-甲氧基苯乙酮合成路线 （共 35 条）
反应条件
1.1: nitric acid; acetic acid / 18 h / 10 - 20 °C 2.1: zinc; ammonium chloride / ethanol; water / 5 h / Reflux 3.1: sodium methylate / ethylene glycol dimethyl ether / 1 h / 0 °C 3.2: 0 - 20 °C 4.1: trichlorophosphate / 3 h / 110 °C 4.2: Cooling with ice View Scheme
参考文献
WO2011/45084 A1, ;
WO 2011/045084 A1
反应条件
1: 80 percent / bromine / ethanol / 2 h / Ambient temperature 2: 83 percent 3: 91 percent 4: 1.) NaBH4; 2.) H2 / 1.) dioxane; 2.) ethanol View Scheme
参考文献
Crestini, Claudia; D'Auria, Maurizio
Tetrahedron, 1997 , vol. 53, # 23 p. 7877 - 7888
反应条件
1: 1.) 80 deg C, 1 h; 2.) reflux, 5 h 2: 16.4 g / aq. KOH (50percent) / ethanol / 5 h / Heating View Scheme
参考文献
Fujii, Tozo; Ohba, Masashi; Sakaguchi, Jun
Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 9 p. 3628 - 3640
反应条件
copper(ll) bromide in ethanol; chloroform T=70°C; 0.25 h; Microwave irradiation;
参考文献
Ouyang, Xin-Ping; Liu, Chun-Lei; Pang, Yu-Xia; Qiu, Xue-Qing
Chinese Chemical Letters, 2013 , vol. 24, # 12 p. 1091 - 1094
反应条件
bromine in chloroform
参考文献
Fuglseth, Erik; Anthonsen, Thorleif; Hoff, Bard Helge
Tetrahedron Asymmetry, 2006 , vol. 17, # 8 p. 1290 - 1295
反应条件
1: 69 percent / Br2 / CHCl3; CCl4 / 1) 5 deg C, 20 min, 2) 5 deg C -> 40 deg C, 2 h
2: 95 percent / K2CO3 / dimethylformamide / 2 h / 25 °C
3: 1) K2CO3, 2) 1 M NaOH / 1) DMSO, 25 deg C, 10 min, 2) DMSO, H2O, 25 deg C, 1 h
4: 78 percent / NaBH4 / ethanol / 3 h / 5 - 25 °C
5: 28 percent Chromat. / O2, Rose Bengal / acetonitrile / 13 °C / Irradiation
View Scheme
参考文献
Crestini, Claudia; D'Auria, Maurizio
Tetrahedron, 1997 , vol. 53, # 23 p. 7877 - 7888
反应条件
1: 69 percent / Br2 / CHCl3; CCl4 / 1) 5 deg C, 20 min, 2) 5 deg C -> 40 deg C, 2 h
2: 95 percent / K2CO3 / dimethylformamide / 2 h / 25 °C
3: 1) K2CO3, 2) 1 M NaOH / 1) DMSO, 25 deg C, 10 min, 2) DMSO, H2O, 25 deg C, 1 h
View Scheme
参考文献
Crestini, Claudia; D'Auria, Maurizio
Tetrahedron, 1997 , vol. 53, # 23 p. 7877 - 7888
反应条件
1: 1.) 80 deg C, 1 h; 2.) reflux, 5 h
2: 16.4 g / aq. KOH (50percent) / ethanol / 5 h / Heating
3: 94 percent / HCl / 24 h / Ambient temperature
4: 96 percent / LiAlH4 / diethyl ether / 2 h / 0 - 20 °C
View Scheme
参考文献
Fujii, Tozo; Ohba, Masashi; Sakaguchi, Jun
Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 9 p. 3628 - 3640
反应条件
iron; potassium carbonate in dichloromethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; Petroleum ether
参考文献
Zeneca Limited; Zeneca Pharma S.A.
Patent: US6514971 B1, 2003 ;
US 6514971 B1
反应条件
nitric acid; iron; potassium carbonate in dichloromethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; Petroleum ether
参考文献
Hennequin, Laurent Francois Andre
Patent: US2003/212055 A1, 2003 ;
