2-溴-3-4-二甲氧基苯丙酮合成路线 （共 5 条）
反应条件
bromine in chloroform T=62 - 64°C; 0.916667 h; Inert atmosphere;
参考文献
Li, Xu; Jiang, Jian-Hong; Chen, Qingqi; Xiao, Sheng-Xiong; Li, Chuan-Hua; Gu, Hui-Wen; Zhang, Hui; Hu, Ji-Lin; Yao, Fei-Hong; Li, Qiang-Guo
European Journal of Medicinal Chemistry, 2013 , vol. 62, p. 605 - 613
反应条件
1: 75 percent / polyphosphoric acid / 1.5 h / 100 °C 2: 88 percent / Br2 / CHCl3 / 4 h / Ambient temperature View Scheme
参考文献
Perry,C.W. et al.
Journal of Organic Chemistry, 1972 , vol. 37, # 26 p. 4371 - 4376
反应条件
potassium carbonate in butanone Heating;
参考文献
Aveniente, Mario; Pinto, Eduardo F.; Santos, Lourivaldo S.; Rossi-Bergmann, Bartira; Barata, Lauro E.S.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 23 p. 7337 - 7343
反应条件
1.1: potassium tert-butylate / tetrahydrofuran / 0.25 h / 0 - 7 °C / |Inert atmosphere 1.2: 0.28 h / 18 °C 1.3: 0.67 h / -70 - -55 °C 2.1: hydrogenchloride / methanol / 6.5 h / 44 - 54 °C / |Inert atmosphere; |Large scale 3.1: palladium 10 on activated carbon; hydrogen / 1-Propyl acetate / 8 h / 100 °C / 51716.2 Torr View Scheme
参考文献
Li, Xu; Jiang, Jian-Hong; Chen, Qingqi; Xiao, Sheng-Xiong; Li, Chuan-Hua; Gu, Hui-Wen; Zhang, Hui; Hu, Ji-Lin; Yao, Fei-Hong; Li, Qiang-Guo
European Journal of Medicinal Chemistry, 2013 , vol. 62, p. 605 - 613
反应条件
1.1: potassium tert-butylate / tetrahydrofuran / 0.25 h / 0 - 7 °C / |Inert atmosphere 1.2: 0.28 h / 18 °C 1.3: 0.67 h / -70 - -55 °C 2.1: hydrogenchloride / methanol / 6.5 h / 44 - 54 °C / |Inert atmosphere; |Large scale 3.1: palladium 10 on activated carbon; hydrogen / 1-Propyl acetate / 3 h / 100 °C / 51716.2 Torr View Scheme
参考文献
Li, Xu; Jiang, Jian-Hong; Chen, Qingqi; Xiao, Sheng-Xiong; Li, Chuan-Hua; Gu, Hui-Wen; Zhang, Hui; Hu, Ji-Lin; Yao, Fei-Hong; Li, Qiang-Guo
European Journal of Medicinal Chemistry, 2013 , vol. 62, p. 605 - 613
