5-(哌嗪-1-基)苯并呋喃-2-甲酰胺合成路线 （共 12 条）
反应条件
hydrogenchloride; Pd(dba)2 in diethylene glycol dimethyl ether; water
反应条件
hydrogenchloride; Pd(dba)2 in water; ethyl acetate; toluene
反应条件
in methanol hydrochloric acid
参考文献
US5723614 A1, ;
US 5723614 A
反应条件
1: hydrogen / methanol / 14 h / 35 - 60 °C / 4500.45 Torr 2: N-ethyl-N,N-diisopropylamine / 10 h / 120 °C 3: hydrogen bromide; 4-hydroxy-benzoic acid / acetic acid / 50 °C View Scheme
反应条件
1.1: sulfuric acid; nitric acid / 5 - 35 °C 2.1: acetic anhydride / 0.25 h / 35 °C 2.2: 8 h / 125 °C 3.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 35 - 115 °C 3.2: 10 °C / pH 8 - 9 4.1: hydrogen / methanol / 14 h / 35 - 60 °C / 4500.45 Torr 5.1: N-ethyl-N,N-diisopropylamine / 10 h / 120 °C 6.1: hydrogen bromide; 4-hydroxy-benzoic acid / acetic acid / 50 °C View Scheme
反应条件
1.1: sodium hydroxide / water / 3 h / 30 - 100 °C 2.1: sulfuric acid; nitric acid / 5 - 35 °C 3.1: acetic anhydride / 0.25 h / 35 °C 3.2: 8 h / 125 °C 4.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 35 - 115 °C 4.2: 10 °C / pH 8 - 9 5.1: hydrogen / methanol / 14 h / 35 - 60 °C / 4500.45 Torr 6.1: N-ethyl-N,N-diisopropylamine / 10 h / 120 °C 7.1: hydrogen bromide; 4-hydroxy-benzoic acid / acetic acid / 50 °C View Scheme
反应条件
1.1: acetic anhydride / 0.25 h / 35 °C 1.2: 8 h / 125 °C 2.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 35 - 115 °C 2.2: 10 °C / pH 8 - 9 3.1: hydrogen / methanol / 14 h / 35 - 60 °C / 4500.45 Torr 4.1: N-ethyl-N,N-diisopropylamine / 10 h / 120 °C 5.1: hydrogen bromide; 4-hydroxy-benzoic acid / acetic acid / 50 °C View Scheme
反应条件
1.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 35 - 115 °C 1.2: 10 °C / pH 8 - 9 2.1: hydrogen / methanol / 14 h / 35 - 60 °C / 4500.45 Torr 3.1: N-ethyl-N,N-diisopropylamine / 10 h / 120 °C 4.1: hydrogen bromide; 4-hydroxy-benzoic acid / acetic acid / 50 °C View Scheme
反应条件
1: tributyl-amine / 43 h / 73 - 77 °C 2: sulfuric acid / 0.25 h / 25 - 102 °C 3: ammonia / methanol / 25 - 30 °C View Scheme
反应条件
1: 3-(4-chloro-butyl)-5-cyanoindole With sodium iodide in N,N-dimethyl-formamide T=25 - 30°C; 0.25 h; 2: 1-(2-aminocarbonylbenzofuran-5-yl)piperazine With tetrabutylammomium bromide; sodium hydrogencarbonate in N,N-dimethyl-formamide T=110 - 115°C; 1.25 h; Reagent/catalystTemperatureTimeSolvent;
参考文献
DR.REDDYS LABORATORIES LIMITED; IQBAL, Javed; ORUGANTI, Srinivas; RAPOLU, Rajesh Kumar; PEDDY, Vishweshwar; BOGE, Rajesham; PATHIVADA, Deepika; VELAGA, Dharma Jagannadha Rao; YARRAGUNTLA, Sesha Reddy; BADDAM, Sudhakar Reddy; NAREDLA, Anitha; DONIPARTHI, Kiran Kumar; NADGOUD, Ramesh Kumar; PAGADALA, Narasimha Rao; UNNIARAN, Syam Kumar; RAMAKRISHNAN, Srividya
Patent: WO2013/168126 A1, 2013 ;
Location in patent: Page/Page column 75-78 ;
