(R)-3-氨基-2-苄基丙酸合成路线 （共 27 条）
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 6 h;
参考文献
Tessier, Arnaud; Lahmar, Nour; Pytkowicz, Julien; Brigaud, Thierry
Journal of Organic Chemistry, 2008 , vol. 73, # 10 p. 3970 - 3973
反应条件
palladium 10 on activated carbon; hydrogen in methanol
T=20°C; P=760.051 Torr; 16 h;
参考文献
Bandala, Yamir; Reyes-Rangel, Gloria; Obregon-Zuniga, Arturo; Cruz-Hernandez, Carlos; Corzo, Gerardo; Juaristi, Eusebio
European Journal of Organic Chemistry, 2014 , vol. 2014, # 11 p. 2275 - 2283
反应条件
hydrogen; palladium on activated charcoal in methanol
3 h;
参考文献
Ma, Da-You; Wang, De-Xian; Zheng, Qi-Yu; Wang, Mei-Xiang
Tetrahedron Asymmetry, 2006 , vol. 17, # 16 p. 2366 - 2376
反应条件
ammonium formate; 10percent Pd/C in methanol
T=60°C;
参考文献
Lee, Hee-Seung; Park, Jin-Seong; Kim, Byeong Moon; Gellman, Samuel H.
Journal of Organic Chemistry, 2003 , vol. 68, # 4 p. 1575 - 1578
反应条件
1: 90 percent / HBr; H2SO4 / H2O / 20 °C
2: 77.8 percent / dimethylformamide / 20 °C
3: hydrogen; chiral ManniPhos-based ligand / [Rh(COD)2]BF4 / CH2Cl2 / 36 h / 20 °C / 64600 Torr
4: HCl / H2O / 24 h / Heating
View Scheme
参考文献
Huang, Hanmin; Liu, Xiongcai; Deng, Jun; Qiu, Min; Zheng, Zhuo
Organic Letters, 2006 , vol. 8, # 15 p. 3359 - 3362
反应条件
1: 85.1 percent / DABCO / 24 h / 20 °C
2: 90 percent / HBr; H2SO4 / H2O / 20 °C
3: 77.8 percent / dimethylformamide / 20 °C
4: hydrogen; chiral ManniPhos-based ligand / [Rh(COD)2]BF4 / CH2Cl2 / 36 h / 20 °C / 64600 Torr
5: HCl / H2O / 24 h / Heating
View Scheme
参考文献
Huang, Hanmin; Liu, Xiongcai; Deng, Jun; Qiu, Min; Zheng, Zhuo
Organic Letters, 2006 , vol. 8, # 15 p. 3359 - 3362
反应条件
1: 77.8 percent / dimethylformamide / 20 °C
2: hydrogen; chiral ManniPhos-based ligand / [Rh(COD)2]BF4 / CH2Cl2 / 36 h / 20 °C / 64600 Torr
3: HCl / H2O / 24 h / Heating
View Scheme
参考文献
Huang, Hanmin; Liu, Xiongcai; Deng, Jun; Qiu, Min; Zheng, Zhuo
Organic Letters, 2006 , vol. 8, # 15 p. 3359 - 3362
反应条件
1: 86 percent / triethylamine / dimethylformamide / 24 h / 20 °C
2: LHMDS / tetrahydrofuran / 0.5 h / -78 °C
3: HCOONH4 / 10percent Pd/C / methanol / 60 °C
View Scheme
参考文献
Lee, Hee-Seung; Park, Jin-Seong; Kim, Byeong Moon; Gellman, Samuel H.
Journal of Organic Chemistry, 2003 , vol. 68, # 4 p. 1575 - 1578
反应条件
1: 66 percent / t-BuOK / tetrahydrofuran / 12 h / 0 - 70 °C
2: 93 percent / LHMDS / tetrahydrofuran / 6 h / -78 - 20 °C
3: 86 percent / triethylamine / dimethylformamide / 24 h / 20 °C
4: LHMDS / tetrahydrofuran / 0.5 h / -78 °C
5: HCOONH4 / 10percent Pd/C / methanol / 60 °C
View Scheme
参考文献
Lee, Hee-Seung; Park, Jin-Seong; Kim, Byeong Moon; Gellman, Samuel H.
Journal of Organic Chemistry, 2003 , vol. 68, # 4 p. 1575 - 1578
反应条件
1: 93 percent / LHMDS / tetrahydrofuran / 6 h / -78 - 20 °C
2: 86 percent / triethylamine / dimethylformamide / 24 h / 20 °C
3: LHMDS / tetrahydrofuran / 0.5 h / -78 °C
4: HCOONH4 / 10percent Pd/C / methanol / 60 °C
View Scheme
参考文献
Lee, Hee-Seung; Park, Jin-Seong; Kim, Byeong Moon; Gellman, Samuel H.
Journal of Organic Chemistry, 2003 , vol. 68, # 4 p. 1575 - 1578
