1,3-丙酮二羧酸二甲酯合成路线 （共 133 条）
反应条件
sodium methylate 1.) MeOH, r.t., overnight, 2.) H2O, 40 deg C, baker's yeast; Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Arslan, Tuncer; Benner, Steven A.
Journal of Organic Chemistry, 1993 , vol. 58, # 8 p. 2260 - 2264
反应条件
1: 60 percent / HCl / methanol / 3 h 2: 69 percent / aq. KOH / 1 h / 20 °C View Scheme
参考文献
Dubovik; Garazd; Khilya
Chemistry of Natural Compounds, 2004 , vol. 40, # 5 p. 434 - 443
反应条件
1.1: acetic anhydride; acetic acid / 1.5 h / 120 °C 1.2: 1 h / Cooling with ice 2.1: triethylamine; trichlorophosphate / 2 h / 0 - 120 °C View Scheme
参考文献
GLENMARK PHARMACEUTICALS S.A.; GHARAT, Laxmikant Atmaram; GAJERA, Jitendra Maganbhai; NARAYANA, Lakshminarayana; KHAIRATKAR-JOSHI, Neelima; KATTIGE, Vidya Ganapati
Patent: WO2012/110860 A1, 2012 ;
WO 2012/110860 A1
反应条件
1: 32 percent / p-toluenesulfonic acid / toluene / 24 h / Heating 2: 75 percent / sodium hydride / dimethylformamide / 1 h 3: 74 percent / ammonia / methanol / 72 h / Ambient temperature 4: 57 percent / phosphoryl chloride / 2 h / Heating 5: 18 percent / liquid NH3 / 144 h / 100 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 10 p. 2034 - 2037
反应条件
zirconium tetrachloride T=70°C; Pechmann condensation; 0.133333 h;
参考文献
Smitha; Reddy, Ch. Sanjeeva
Synthetic Communications, 2004 , vol. 34, # 21 p. 3997 - 4003
反应条件
sulfuric acid in methanol T=20°C; Pechmann condensation;
参考文献
Dubovik; Garazd; Khilya
Chemistry of Heterocyclic Compounds, 2007 , vol. 43, # 3 p. 277 - 281
反应条件
1: With Ni(acac)2 in 1,4-dioxane 16 h; Reflux; 2: With trichlorophosphate 0.583333 h; Reflux;
参考文献
RVX Therapeutics Inc.; McLure, Kevin G.; Young, Peter Ronald
Patent: US2013/281397 A1, 2013 ;
Location in patent: Paragraph 0588; 0589 ;
反应条件
1: bis(acetylacetonate)nickel(II) / 1,4-dioxane / 16 h / Reflux 2: N-ethyl-N,N-diisopropylamine; trichlorophosphate / 72 h / 20 °C View Scheme
参考文献
RVX Therapeutics Inc.; McLure, Kevin G.; Young, Peter R.
Patent: US2013/281398 A1, 2013 ;
反应条件
triethylamine in methanol 24 h; Heating;
参考文献
Bulletin des Societes Chimiques Belges, , vol. 96, # 10 p. 823 - 824
反应条件
hydrogenchloride; sodium acetate; sodium nitrite 1.) water, below 5 deg C, 2.) ethanol, water, 30 min; Yield given. Multistep reaction;
参考文献
Schober, Bernt D.; Megyeri, Gabor; Kappe, Thomas
Journal of Heterocyclic Chemistry, 1989 , vol. 26, p. 169 - 176
