1,3-丙酮二羧酸二甲酯合成路线 （共 133 条）
反应条件
1: 88 percent / benzene / 18 h / Heating
2: 99 percent / H2 / 1percent PtO2/C / ethanol
3: 86 percent / LiAlH4 / tetrahydrofuran / 2 h / Ambient temperature
4: 59 percent / CBr4, Ph3P / tetrahydrofuran / 2 h / Heating
View Scheme
参考文献
Yamagiwa, Yoshiro; Koreishi, Yoshiro; Kiyozumi, Satoshi; Kobayashi, Masanori; Kamikawa, Tadao; Tsukino, Mitsuji; Goi, Hironori; Yamamoto, Mikiko; Munakata, Megumu
Bulletin of the Chemical Society of Japan, 1996 , vol. 69, # 11 p. 3317 - 3323
反应条件
in benzene
8 h; Reflux;
参考文献
Laleu, Benoit; Gaggini, Francesca; Orchard, Mike; Fioraso-Cartier, Laetitia; Cagnon, Laurene; Houngninou-Molango, Sophie; Gradia, Angelo; Duboux, Guillaume; Merlot, Cedric; Heitz, Freddy; Szyndralewiez, Cedric; Page, Patrick
Journal of Medicinal Chemistry, 2010 , vol. 53, # 21 p. 7715 - 7730
反应条件
in toluene
T=100°C; 36 h;
参考文献
Storey, Anthony; Davis, Julie; Ricketts, Sally-Ann; Medizabal, Marivi; Cuthbertson, Alan; Arukwe, Joseph; Heywood, Kirsty; Wilson, Ian; Wynn, Duncan; Schafers, Michael; Levkau, Bodu; Wagner, Stefan; Breyholz, Hans-Jorg; Kopka, Klaus
Patent: US2007/71670 A1, 2007 ;
Location in patent: Page/Page column 12 ;
