titanium(IV) isopropylate; isopropylmagnesium chloride in diethyl ether T=-45°C; 1 h;

1.1: lithium chloride / water; dimethyl sulfoxide / 160 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C 2.2: 3 h / -78 °C View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1.1: 81 percent / Ti(O-i-Pr)4; i-PrMgCl / diethyl ether / 1 h / -50 - -40 &deg;C<br />2.1: NaH / tetrahydrofuran / 1 h / 0 - 20 &deg;C<br />2.2: 79 percent / tetrahydrofuran / 20 &deg;C<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3556712', constants.ctx, '0')">potassium <i>tert</i>-butylate</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a> <br />T=0&deg;C;&nbsp;0.5&nbsp;h;&nbsp;&nbsp;Inert atmosphere;&nbsp;&nbsp;Reagent/catalystSolventTemperature;&nbsp;<br /> <br /> &nbsp;