5-(4-羟基-苯基)-[1,2]二硫醇-3-硫酮合成路线 （共 12 条）
反应条件
sulfur in N,N-dimethyl-formamide 8 h; Heating;
参考文献
ANTIBE THERAPEUTICS INC.; CIRINO, Giuseppe; CALIENDO, Giuseppe; SANTAGADA, Vincenzo; FIORUCCI, Stefano
Patent: WO2006/125295 A1, 2006 ;
Location in patent: Page/Page column 40-41; 51 ;
反应条件
1: With sulfur in N,N-dimethyl-formamide 8 h; Heating / reflux; 2: With hydrogenchloride in water Reflux;
参考文献
ANTIBE THERAPEUTICS INC.
Patent: US2008/207564 A1, 2008 ;
Location in patent: Page/Page column 11; 14-16 ;
反应条件
pyridine hydrochloride T=215°C; 3 h; Inert atmosphere;
参考文献
Guan, Mei; Fan, Wei; Qian, Shan; Xiao, Rui Qi; Wu, Yong
Chinese Chemical Letters, 2010 , vol. 21, # 12 p. 1427 - 1429
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 2 h;
参考文献
Zanatta, Shannon D.; Jarrott, Bevyn; Williams, Spencer J.
Australian Journal of Chemistry, 2010 , vol. 63, # 6 p. 946 - 957
反应条件
1.1: N,N'-dimethyl-N,N'-propyleneurea; potassium hydride / tetrahydrofuran; mineral oil / 0.25 h 1.2: 0.17 h 1.3: 0 °C 2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C View Scheme
参考文献
Zanatta, Shannon D.; Jarrott, Bevyn; Williams, Spencer J.
Australian Journal of Chemistry, 2010 , vol. 63, # 6 p. 946 - 957
反应条件
1.1: acetyl chloride; zinc(II) chloride / toluene 2.1: N,N'-dimethyl-N,N'-propyleneurea; potassium hydride / tetrahydrofuran; mineral oil / 0.25 h 2.2: 0.17 h 2.3: 0 °C 3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C View Scheme
参考文献
Zanatta, Shannon D.; Jarrott, Bevyn; Williams, Spencer J.
Australian Journal of Chemistry, 2010 , vol. 63, # 6 p. 946 - 957
反应条件
benzoic acid ethyl ester; sulfur
参考文献
Lozac'h et al.
Bulletin de la Societe Chimique de France, 1953 , p. 1016,1017, 1019
参考文献
Lozac'h et al.
Bulletin de la Societe Chimique de France, 1953 , p. 1016,1017, 1019
反应条件
dicyclohexyl-carbodiimide; 4-(N,N-dimethlyamino)pyridine in dichloromethane T=20°C; 20 h;
参考文献
CTG PHARMA S.R.L.
Patent: WO2006/111791 A1, 2006 ;
Location in patent: Page/Page column 10 ;
反应条件
dicyclohexyl-carbodiimide; 4-(N,N-dimethlyamino)pyridine in dichloromethane T=20°C; 0.666667 h;
参考文献
CTG PHARMA S.R.L.
Patent: WO2006/111791 A1, 2006 ;
Location in patent: Page/Page column 9-10 ;
