6-氯-2,5-二甲基-嘧啶-4-胺合成路线 （共 3 条）
参考文献
SUNOVION PHARMACEUTICALS INC.; CAMPBELL, John, Emerson; HEWITT, Michael, Charles; JONES, Philip; XIE, Linghong
Patent: WO2011/150156 A2, 2011 ;
Location in patent: Page/Page column 124 ;
WO 2011/150156 A2
反应条件
1: POCl3 2: water; NH3 View Scheme
参考文献
Henze et al.
Journal of Organic Chemistry, 1952 , vol. 17, p. 1320,1322
反应条件
1.1: trichlorophosphate / 100 °C 1.2: pH 8 - 9 2.1: ammonium hydroxide / ethanol / 8 h / 80 °C View Scheme
参考文献
SUNOVION PHARMACEUTICALS INC.; CAMPBELL, John, Emerson; HEWITT, Michael, Charles; JONES, Philip; XIE, Linghong
Patent: WO2011/150156 A2, 2011 ;
WO 2011/150156 A2
