3-乙酰氧基-7-氯-1,3-二氢-5-苯基-2H-1,4-苯并二氮杂革-2-酮合成路线 （共 7 条）
反应条件
dipotassium peroxodisulfate; iodine in acetic acid T=65 - 70°C; 8 h; Reagent/catalystTemperatureTime;
参考文献
Cepanec, Ivica; Litvic, Mladen; Pogorelic, Ivan
Organic Process Research and Development, 2006 , vol. 10, # 6 p. 1192 - 1198
反应条件
1: toluene / 3.5 h / 10 - 20 °C 2: 1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane; ammonium acetate / ethanol / 6 h / |Reflux 3: dipotassium peroxodisulfate; iodine / acetic acid / 8 h / 65 - 70 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 10, # 6 p. 1192 - 1198
反应条件
1: 1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane; ammonium acetate / ethanol / 6 h / |Reflux 2: dipotassium peroxodisulfate; iodine / acetic acid / 8 h / 65 - 70 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 10, # 6 p. 1192 - 1198
反应条件
pyridine Ambient temperature;
参考文献
Journal of pharmaceutical sciences, , vol. 78, # 10 p. 789 - 795
反应条件
water; sodium hydroxide in ethanol T=5°C; 1.5 h;
参考文献
Cepanec, Ivica; Litvic, Mladen; Pogorelic, Ivan
Organic Process Research and Development, 2006 , vol. 10, # 6 p. 1192 - 1198
反应条件
in water T=40°C; Reaction rate. pH 2-10, other temperature.; Kinetics;
参考文献
Aso; Yoshioka; Shibazaki; Uchiyama
Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 5 p. 1834 - 1840
反应条件
1: 1.) sodium hydride / 1.) THF, room temperature, 2 h, 2.) THF, room temperature, 4 h
2: tetrahydrofuran / 20 h / Ambient temperature
3: 4 N aq. NaOH / ethanol / 1 h
View Scheme
参考文献
Del Giudice; Gatta; Pandolfi; Settimj
Farmaco, Edizione Scientifica, 1982 , vol. 37, # 5 p. 343 - 352
