4-氨基-5-甲基-3-硝基吡啶合成路线 （共 6 条）
反应条件
sulfuric acid; nitric acid T=20 - 60°C; 15 h;
参考文献
K.U. LEUVEN RESEARCH and DEVELOPMENT; GILEAD SCIENCES, INC.; PUERSTINGER, Gerhard
Patent: WO2005/63744 A2, 2005 ;
Location in patent: Page/Page column 232 ;
反应条件
sulfuric acid T=20°C;
参考文献
Irani, Rostem J.; SantaLucia Jr., John
Nucleosides, Nucleotides and Nucleic Acids, 2002 , vol. 21, # 11-12 p. 737 - 751
反应条件
1: 70 percent / conc. H2SO4; 90 percent HNO3 / 2 h / below 80 deg C 2: 95 percent / H2 / Raney Ni / methanol / 4 h / 3361.46 Torr 3: 84 percent / conc. H2SO4; conc. HNO3 / cooling 4: 54 percent / conc. H2SO4 / 20 °C View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 21, # 11-12 p. 737 - 751
反应条件
1: 95 percent / H2 / Raney Ni / methanol / 4 h / 3361.46 Torr 2: 84 percent / conc. H2SO4; conc. HNO3 / cooling 3: 54 percent / conc. H2SO4 / 20 °C View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 21, # 11-12 p. 737 - 751
反应条件
hydrogenchloride; tin(IV) chloride 0.75 h; Heating;
参考文献
Irani, Rostem J.; SantaLucia Jr., John
Nucleosides, Nucleotides and Nucleic Acids, 2002 , vol. 21, # 11-12 p. 737 - 751
反应条件
hydrogenchloride; iron in ethanol 3 h; Heating / reflux;
参考文献
K.U. LEUVEN RESEARCH and DEVELOPMENT; GILEAD SCIENCES, INC.; PUERSTINGER, Gerhard
Patent: WO2005/63744 A2, 2005 ;
Location in patent: Page/Page column 232 ;
