1-甲基-5-硝基吡唑-4-甲酸合成路线 （共 4 条）
反应条件
1: sodium hydroxide; water / |Reflux 2: sodium nitrite; tetrafluoroboric acid / water View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 7 p. 1961 - 1966
反应条件
1: With tetrafluoroboric acid; sodium nitrite in water 2: With copper; sodium nitrite
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 7 p. 1961 - 1966
反应条件
N,N-dimethyl-formamide in toluene 16 h; Heating / reflux;
参考文献
ELI LILLY and CO.
Patent: WO2009/64802 A2, 2009 ;
Location in patent: Page/Page column 57; 62 ;
WO 2009/064802 A2
反应条件
thionyl chloride in dichloromethane
参考文献
Peet, Norton P.; Malecha, James; LeTourneau, Michael E.; Sunder, Shyam
Journal of Heterocyclic Chemistry, 1989 , vol. 26, p. 257 - 264
