2,4-二氨基-6,7-二苯基-蝶啶合成路线 （共 16 条）
反应条件
ammonium hydroxide in methanol
T=20°C; 240 h;
参考文献
Yao, Qizheng; Pfleiderer, Wolfgang
Helvetica Chimica Acta, 2003 , vol. 86, # 1 p. 1 - 12
反应条件
ethanol; ammonia
T=180 - 190°C;
参考文献
Taylor; Cain
Journal of the American Chemical Society, 1952 , vol. 74, p. 1644,1646
反应条件
ammonium hydroxide in 1,4-dioxane
72 h; Ambient temperature;
参考文献
Taylor, Edward C.; Otiv, S. R.; Durucasu, Inci
Heterocycles, 1993 , vol. 36, # 8 p. 1883 - 1895
反应条件
1: ethanol; butanone
2: ethanol; NH3 / 180 - 190 °C
View Scheme
参考文献
Taylor; Cain
Journal of the American Chemical Society, 1952 , vol. 74, p. 1644,1646
反应条件
hydrogenchloride; sodium hydrogensulfite
参考文献
Mallette et al.
Journal of the American Chemical Society, 1947 , vol. 69, p. 1814
反应条件
1: 94 percent / 3 h / Heating
2: 69 percent / Ph3P; diisopropyl azodicarboxylate / dioxane / 24 h / 75 - 80 °C
3: 58 percent / aq. NH3 / methanol / 240 h / 20 °C
View Scheme
参考文献
Yao, Qizheng; Pfleiderer, Wolfgang
Helvetica Chimica Acta, 2003 , vol. 86, # 1 p. 1 - 12
反应条件
1: 69 percent / Ph3P; diisopropyl azodicarboxylate / dioxane / 24 h / 75 - 80 °C
2: 58 percent / aq. NH3 / methanol / 240 h / 20 °C
View Scheme
参考文献
Yao, Qizheng; Pfleiderer, Wolfgang
Helvetica Chimica Acta, 2003 , vol. 86, # 1 p. 1 - 12
反应条件
1: 20 percent / 4-chlorophenyl phosphorodichloridate, pyridine / 24 h / Ambient temperature
2: 93 percent / aq. NH3 / dioxane / 0.5 h / Ambient temperature
3: 68 percent / aq. NH3 / dioxane / 72 h / Ambient temperature
View Scheme
参考文献
Taylor, Edward C.; Otiv, S. R.; Durucasu, Inci
Heterocycles, 1993 , vol. 36, # 8 p. 1883 - 1895
反应条件
1: 93 percent / aq. NH3 / dioxane / 0.5 h / Ambient temperature
2: 68 percent / aq. NH3 / dioxane / 72 h / Ambient temperature
View Scheme
参考文献
Taylor, Edward C.; Otiv, S. R.; Durucasu, Inci
Heterocycles, 1993 , vol. 36, # 8 p. 1883 - 1895
反应条件
hydrogenchloride; acetic acid
T=150 - 160°C;
参考文献
Burroughs Wellcome and Co.
Patent: US2581889 , 1949 ;
