2′,4′,5′-三甲氧基苯乙酮合成路线 （共 22 条）
反应条件
potassium permanganate anschliessend Behandeln mit wss. H2O2;
参考文献
Bargellini; Avrutin
Gazzetta Chimica Italiana, 1910 , vol. 40 II, p. 349
Gazzetta Chimica Italiana, 1913 , vol. 43 I, p. 165,167 Anm.
参考文献
Bargellini; Avrutin
Gazzetta Chimica Italiana, 1910 , vol. 40 II, p. 349
Gazzetta Chimica Italiana, 1913 , vol. 43 I, p. 165,167 Anm.
反应条件
aluminium trichloride in diethyl ether 48 h; Ambient temperature;
参考文献
Banerji, A.; Goomer, N. C.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 2 p. 144 - 146
反应条件
1: 85.5 percent / aluminium chloride / diethyl ether / 48 h / Ambient temperature 2: 86 percent / 1.) lithium diisopropylamide / tetrahydrofuran / 1.) -30 deg C, 1 h, 2.) -40 deg C, 90 min 3: 90 percent / HCl / methanol / 2.5 h / Heating View Scheme
参考文献
Banerji, A.; Goomer, N. C.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 2 p. 144 - 146
反应条件
1: 85.5 percent / aluminium chloride / diethyl ether / 48 h / Ambient temperature 2: 86 percent / 1.) lithium diisopropylamide / tetrahydrofuran / 1.) -30 deg C, 1 h, 2.) -40 deg C, 90 min 3: 90 percent / HCl / methanol / 2.5 h / Heating 4: 90 percent / LAH / diethyl ether / 3 h / Heating 5: 76 percent / p-toluenesulphonic acid / benzene / Heating View Scheme
参考文献
Banerji, A.; Goomer, N. C.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 2 p. 144 - 146
反应条件
peracetic acid; perchloric acid; acetic anhydride in acetic acid
参考文献
Huee,R. et al.
Bulletin de la Societe Chimique de France, 1970 , p. 3617 - 3624
反应条件
1: 55 percent / NaBH4 / ethanol / 0.5 h / Heating 2: 59 percent / NaOAc; Ac2O / 12 h / Heating View Scheme
参考文献
Cruz; Garduno; Salazar; Martinez; Jimenez-Vazquez; Diaz; Chamorro; Tamariz
Arzneimittel-Forschung/Drug Research, 2001 , vol. 51, # 7 p. 535 - 544
反应条件
hydrogen; palladium on activated charcoal in ethanol P=760 Torr; 1.5 h;
参考文献
Hoegberg, Thomas; Bengtsson, Stefan; Paulis, Tomas de; Johansson, Lars; Stroem, Peter; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 4 p. 1155 - 1163
反应条件
aluminium trichloride in dichloromethane
T=10°C; 1 h;
参考文献
Hoegberg, Thomas; Bengtsson, Stefan; Paulis, Tomas de; Johansson, Lars; Stroem, Peter; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 4 p. 1155 - 1163
反应条件
hydrogenchloride; aluminium trichloride in dichloromethane
参考文献
Taiho Pharmaceutical Co., Ltd.
Patent: US5786355 A1, 1998 ;
