甲基(2-(2,2,2-三氟乙酰氨基)乙基)氨基甲酸叔丁酯合成路线 （共 3 条）
反应条件
in tetrahydrofuran T=10 - 20°C; 26 h;
参考文献
Martins; Baruah; Kramarczyk; Saluta; Day; Kucera; Bierbach
Journal of Medicinal Chemistry, 2001 , vol. 44, # 25 p. 4492 - 4496
反应条件
1: ethyl-α,α,α-trifluoroacetate; N-methyl-1,2-ethanediamine 2: di-tert-butyl dicarbonate
参考文献
FOB SYNTHESIS
Patent: WO2005/123066 A1, 2005 ;
Location in patent: Page/Page column 77-78 ;
反应条件
sodium hydroxide in methanol T=15 - 35°C; 48 h;
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 25 p. 4492 - 4496
