4-甲氧基-1,3-苯并二氧戊环合成路线 （共 26 条）
反应条件
potassium carbonate; copper(II) oxide in N,N-dimethyl-formamide 8 h; Heating;
参考文献
Loriot; Robin; Brown
Tetrahedron, 1984 , vol. 40, # 13 p. 2529 - 2535
反应条件
in DMF (N,N-dimethyl-formamide) T=90°C; 4 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2004/46120 A2, 2004 ;
Location in patent: Page 171 ;
WO 2004/046120 A2
反应条件
caesium carbonate in N,N-dimethyl-formamide T=20 - 110°C;
参考文献
Cabiddu, Maria Grazia; Cadoni, Enzo; De Montis, Stefania; Fattuoni, Claudia; Melis, Stefana; Usai, Michele
Tetrahedron, 2003 , vol. 59, # 24 p. 4383 - 4387
反应条件
potassium carbonate in acetone T=50°C; 5 h; Yield given;
参考文献
Ikeya, Yukinobu; Taguchi, Heihachiro; Yoshioka, Itiro
Chemical & Pharmaceutical Bulletin, 1981 , vol. 29, # 10 p. 2893 - 2898
反应条件
potassium hydroxide; copper bronze T=110°C;
参考文献
Campbell et al.
Journal of Organic Chemistry, 1951 , vol. 16, p. 1736,1740
反应条件
sodium hydride 1.) HMPT, room temp.; 2.) room temp., 20 min; Yield given. Multistep reaction;
参考文献
Castillo, P.; Rodriguez-Ubis, J. C.; Rodriguez, F.
Synthesis, 1986 , # 10 p. 839 - 840
反应条件
sodium hydroxide; acetone
参考文献
Baker et al.
Journal of the Chemical Society, 1932 , p. 1281
参考文献
Brown, Eric; Loriot, Michel; Robin, Jean-Pierre
Tetrahedron Letters, 1982 , vol. 23, # 9 p. 949 - 952
反应条件
tin(IV) chloride in dichloromethane T=10°C; 0.166667 h;
参考文献
Daukshas, V.K.; Udrenaite, E.B.; Kuleshyus, V.A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1982 , vol. 18, # 12 p. 1243 - 1246
Khimiya Geterotsiklicheskikh Soedinenii, 1982 , vol. 18, # 12 p. 1614 - 1617
反应条件
trichlorophosphate 1.) 35-38 deg C, 5 h, 2.) 50 deg C, 1.5 h; Yield given. Title compound not separated from byproducts;
参考文献
Shirasaka, Tadashi; Takuma, Yuki; Imaki, Naoshi
Synthetic Communications, 1990 , vol. 20, # 8 p. 1213 - 1221
