trifluoroacetic acid in dichloromethane T=0°C; 4 h;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '14209310', constants.ctx, '0')">Pd⁰(tris(tert-butyl)phosphine)₂</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '472690', constants.ctx, '0')">toluene-4-sulfonic acid</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '605283', constants.ctx, '0')">triethylamine</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '8127935', constants.ctx, '0')">sodium chloride</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a> <br />T=22&deg;C;&nbsp;Heck coupling;&nbsp;14&nbsp;h;&nbsp;&nbsp;Inert atmosphere;&nbsp;<br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '6184400', constants.ctx, '0')">cesium fluoride</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '661212', constants.ctx, '0')">tris-(o-tolyl)phosphine</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '11324644', constants.ctx, '0')">palladium diacetate</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '741857', constants.ctx, '0')">acetonitrile</a> <br />T=45&deg;C;&nbsp;Heck reaction;&nbsp;4&nbsp;h;&nbsp;<br /> &nbsp;

Stage #1: <a href="#" onclick="return RXDsubstances(event, this, '2050126', constants.ctx, '0')">t-butyl 2-(diethoxyphosphoryl)acetate</a> <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1209227', constants.ctx, '0')">n-butyllithium</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '1730733', constants.ctx, '0')">hexane</a> <br />T=-78&deg;C;&nbsp;Horner-Wadsworth-Emmons reaction;&nbsp;0.5&nbsp;h;&nbsp;<br />Stage #2: <a href="#" onclick="return RXDsubstances(event, this, '606013', constants.ctx, '0')">3-methoxy-benzaldehyde</a> &nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '1730733', constants.ctx, '0')">hexane</a> <br />T=-78 - 20&deg;C;&nbsp;&nbsp;Further stages.;&nbsp;<br /> &nbsp;