1-(7-溴-3,4-二氢异喹啉-2(1H)-基)-2,2,2-三氟乙酮合成路线 （共 7 条）
反应条件
formaldehyd; sulfuric acid in water T=20°C; 18 h;
参考文献
NOVARTIS AG
Patent: WO2008/76954 A2, 2008 ;
Location in patent: Page/Page column 51 ;
WO 2008/076954 A2
反应条件
sulfuric acid; acetic acid T=20°C;
参考文献
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA
Patent: WO2004/87714 A1, 2004 ;
Location in patent: Page 71 ;
WO 2004/087714 A1
反应条件
sulfuric acid in acetic acid T=20°C; 16 h;
参考文献
Stokker
Tetrahedron Letters, 1996 , vol. 37, # 31 p. 5453 - 5456
反应条件
pyridine; 4-(N,N-dimethlyamino)pyridine in chloroform T=20°C; 20 h; Cooling with ice;
参考文献
Taisho Pharmaceutical Co., Ltd.; BUSUJIMA, Tsuyoshi; OI, Takahiro; TANAKA, Hiroaki; SHIRASAKI, Yoshihisa; IWAKIRI, Kanako; SATO, Nagaaki; TOKITA, Shigeru
Patent: EP2687507 A1, 2014 ;
Location in patent: Paragraph 0209 ;
反应条件
1: 5.88 g / 0.5 h / -5 °C 2: 94 percent / 40 percent H2SO4 / acetic acid / 16 h / 20 °C View Scheme
参考文献
Stokker
Tetrahedron Letters, 1996 , vol. 37, # 31 p. 5453 - 5456
反应条件
1: (R)-4-bromo-α-phenethylamine; trifluoroacetic anhydride 2: formaldehyd Acidic conditions;
参考文献
Pfizer Inc
Patent: US2005/182079 A1, 2005 ;
Location in patent: Page/Page column 11 ;
反应条件
water; sodium carbonate in methanol T=60°C; 1 h;
参考文献
NOVARTIS AG
Patent: WO2008/76954 A2, 2008 ;
Location in patent: Page/Page column 51 ;
WO 2008/076954 A2
