(+)-5-氨基-3-(S)-异丁基戊二酸合成路线 （共 8 条）
反应条件
ammonia in water T=20°C; 4 h; optical yield given as percent ee;
参考文献
THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN; CONNON, Stephen Joseph; PESCHIULLI, Aldo; PROCURANTI, Barbara
Patent: WO2011/70028 A1, 2011 ;
Location in patent: Page/Page column 34 ;
反应条件
1: With ammonia in water T=20°C; 92 h; 2: With hydrogenchloride in water pH=3;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES, LTD.; TEVA PHARMACEUTICAL USA, INC.
Patent: WO2009/158343 A1, 2009 ;
Location in patent: Page/Page column 16-17 ;
反应条件
1: With (S)-1-phenyl-ethylamine in ethanol; chloroform 0.75 h; Reflux; 2: With hydrogenchloride in ethanol; chloroform; water 0.75 h; Cooling;
参考文献
Sripathi, Somaiah; Somesetti, Narender Rao; Veeramalla, Raju; Challa, Nageswar Rao; Peddi, Srinivasa Rao; Karnati, Venugopal Reddy
Arkivoc, 2010 , vol. 2010, # 10 p. 266 - 275
反应条件
(R)-1-phenyl-ethyl-amine Resolution of racemate;
参考文献
Chavan, Anil B.; Maikap, Golak C.; Gurjar, Mukund K.
Organic Process Research and Development, 2009 , vol. 13, # 4 p. 812 - 814
反应条件
1: With toluene-4-sulfonic acid in toluene Reflux; 2: With sodium hydroxide in water; toluene T=25 - 65°C; 3: With hydrogenchloride in water T=10 - 15°C; 1.5 h; Product distribution / selectivity;
参考文献
WO2011/77463 A1, ;
Page/Page column 21 ;
反应条件
1.1: toluene-4-sulfonic acid / toluene / Reflux 1.2: 25 - 65 °C 1.3: 1.5 h / 10 - 15 °C 2.1: chloroform / 0.5 h / 50 - 55 °C 3.1: sodium hydroxide; bromine / water / 1.25 h / -5 - 55 °C 3.2: 0 - 5 °C / pH 6.7 View Scheme
反应条件
1.1: toluene-4-sulfonic acid / toluene / Reflux 1.2: 25 - 65 °C 1.3: 1.5 h / 10 - 15 °C 2.1: chloroform / 0.5 h / 50 - 55 °C 3.1: hydrogenchloride / water / 1.47 h / 20 - 25 °C View Scheme
反应条件
hydrogenchloride; water 24 h; Reflux;
参考文献
Organic Process Research and Development, , vol. 13, # 4 p. 812 - 814
