(R)-(-)-3-(氨甲酰甲基)-5-甲基己酸合成路线 （共 28 条）
反应条件
1: With water; sodium hydroxide 5 h; Reflux; 2: With hydrogenchloride in water pH=7; Reflux;
参考文献
Arkivoc, , vol. 2010, # 10 p. 266 - 275
反应条件
1: With potassium hydroxide in water T=0°C; 30 h; 2: With potassium hypobromide in water T=0 - 80°C; 1.16667 h; 3: With acetic acid in water T=80 - 90°C; 0.5 h;
参考文献
Dr. Braja Sundar Pradhan
Patent: WO2012/93411 A2, 2012 ;
Location in patent: Page/Page column 30 ;
反应条件
1: With sodium hydroxide; bromine in water T=5 - 35°C; 2: With sulfuric acid in 2-methyl-propan-1-ol; water T=35°C; pH=0.5 - 3; 3: With tributyl-amine T=0 - 20°C; 2 - 8 h;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICAL USA, INC.
Patent: WO2009/46309 A2, 2009 ;
Location in patent: Page/Page column 18 ;
反应条件
1: With potassium hydroxide in water T=0°C; 30 h; 2: With potassium hypobromide in water T=0 - 80°C; 1.16667 h; 3: With acetic acid in water T=80 - 90°C; 0.5 h;
参考文献
Dr. Braja Sundar Pradhan
Patent: WO2012/93411 A2, 2012 ;
Location in patent: Page/Page column 30 ;
反应条件
1: With sodium hydroxide; bromine in water T=5 - 35°C; 2: With sulfuric acid in 2-methyl-propan-1-ol; water T=35°C; pH=0.5 - 3; 3: With tributyl-amine T=0 - 20°C; 2 - 8 h;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICAL USA, INC.
Patent: WO2009/46309 A2, 2009 ;
Location in patent: Page/Page column 18 ;
反应条件
1: With sodium hydroxide; bromine in water T=5 - 35°C; 2: With sulfuric acid in 2-methyl-propan-1-ol; water T=35°C; pH=0.5 - 3; 3: With tributyl-amine T=0 - 20°C; 2 - 8 h;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICAL USA, INC.
Patent: WO2009/46309 A2, 2009 ;
Location in patent: Page/Page column 18 ;
反应条件
1: With potassium hydroxide in water
T=0°C; 30 h;
2: With potassium hypobromide in water
T=0 - 80°C; 1.16667 h;
3: With acetic acid in water
T=80 - 90°C; 0.5 h;
参考文献
Dr. Braja Sundar Pradhan
Patent: WO2012/93411 A2, 2012 ;
Location in patent: Page/Page column 30 ;
反应条件
1: With sodium hydroxide; bromine in water
T=5 - 35°C;
2: With sulfuric acid in 2-methyl-propan-1-ol; water
T=35°C; pH=0.5 - 3;
3: With tributyl-amine
T=0 - 20°C; 2 - 8 h;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICAL USA, INC.
Patent: WO2009/46309 A2, 2009 ;
Location in patent: Page/Page column 18 ;
