(R)-(-)-3-(氨甲酰甲基)-5-甲基己酸合成路线 （共 28 条）
反应条件
1.1: urea / 12 h / 130 - 135 °C 1.2: 60 - 90 °C 2.1: chloroform / 0.5 h / 50 - 55 °C 3.1: hydrogenchloride / water / 1.47 h / 20 - 25 °C View Scheme
反应条件
1.1: ammonia / water; tert-butyl methyl ether / 0 - 20 °C 1.2: pH 2 2.1: acetone / water / 80 °C 3.1: ammonia / water / 5 h / 80 °C 3.2: 0 °C / pH 1 View Scheme
反应条件
1.1: n-dipropylamine / 16 h / 15 - 55 °C 2.1: hydrogen bromide / water / 72 h / 100 °C 3.1: acetyl chloride / 3.08 h / 20 - 55 °C / Inert atmosphere 4.1: ammonia / water; tert-butyl methyl ether / 0 - 20 °C 4.2: pH 2 5.1: acetone / water / 80 °C 6.1: ammonia / water / 5 h / 80 °C 6.2: 0 °C / pH 1 View Scheme
反应条件
1.1: hydrogen bromide / water / 72 h / 100 °C 2.1: acetyl chloride / 3.08 h / 20 - 55 °C / Inert atmosphere 3.1: ammonia / water; tert-butyl methyl ether / 0 - 20 °C 3.2: pH 2 4.1: acetone / water / 80 °C 5.1: ammonia / water / 5 h / 80 °C 5.2: 0 °C / pH 1 View Scheme
反应条件
1.1: immobilized lipase B from Candida antartica; sodium hydroxide / aq. phosphate buffer / 15.6 h / 25 °C / pH 7 / |Enzymatic reaction 2.1: Mg3N2 / methanol / 16 h / 20 - 80 °C 2.2: pH 3 - 4 View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 11, # 22 p. 3635 - 3641
反应条件
1.1: chloroformic acid ethyl ester; triethylamine / acetone / -20 °C / Inert atmosphere 1.2: 2 h / -20 °C 1.3: 0 °C 2.1: acetone / water / 80 °C 3.1: ammonia / water / 5 h / 80 °C 3.2: 0 °C / pH 1 View Scheme
反应条件
1.1: toluene-4-sulfonic acid / toluene / Reflux 1.2: 25 - 65 °C 1.3: 1.5 h / 10 - 15 °C 2.1: chloroform / 0.5 h / 50 - 55 °C 3.1: hydrogenchloride / water / 1.47 h / 20 - 25 °C View Scheme
反应条件
(R)-1-phenyl-ethyl-amine Resolution of racemate;
参考文献
Organic Process Research and Development, , vol. 13, # 4 p. 812 - 814
反应条件
bromine; sodium hydroxide in water Hofmann reaction; CoolingReflux;
参考文献
Sripathi, Somaiah; Somesetti, Narender Rao; Veeramalla, Raju; Challa, Nageswar Rao; Peddi, Srinivasa Rao; Karnati, Venugopal Reddy
Arkivoc, 2010 , vol. 2010, # 10 p. 266 - 275
反应条件
1: With sodium hydroxide; bromine in water T=10 - 80°C; 0.5 h; 2: With sulfuric acid in 2-methyl-propan-1-ol; water T=20 - 25°C; pH=2; 3: With tributyl-amine in 2-methyl-propan-1-ol Product distribution / selectivity;
参考文献
WO2007/35789 A1, ;
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