(R)-(-)-3-(氨甲酰甲基)-5-甲基己酸合成路线 （共 28 条）
反应条件
ammonia in water T=40°C;
参考文献
WO2010/86429 A2, ;
Page/Page column 27 ;
反应条件
1: With ammonia in water T=80°C; 5 h; 2: With hydrogenchloride in water T=0°C; pH=1;
参考文献
WO2012/93411 A2, ;
Page/Page column 23 ;
反应条件
1: With ammonia in water T=20 - 80°C; P=760.051 - 1520.1 Torr; 6 - 92 h; 2: With hydrogenchloride in water pH=1 - 3; Product distribution / selectivity;
参考文献
US2007/293694 A1, ;
Page/Page column 10-11 ;
反应条件
hydrogenchloride in water T=31°C; pH=1.7;
参考文献
WO2009/4643 A2, ;
Page/Page column 27 ;
反应条件
hydrogenchloride in water T=60 - 62°C;
参考文献
WO2008/4044 A1, ;
Page/Page column 12 ;
反应条件
1: With ammonia; water; lithium in tetrahydrofuran T=-40°C; 6 - 10 h; 2: With hydrogenchloride in water pH=1.5 - 1.7; Product distribution / selectivity;
参考文献
WO2007/35789 A1, ;
Page/Page column 28-29 ;
反应条件
1: With ammonia in water T=20°C; 92 h; 2: With hydrogenchloride in water pH=3;
参考文献
WO2009/158343 A1, ;
Page/Page column 16-17 ;
反应条件
1: With Mg3N2 in methanol T=20 - 80°C; 16 h; 2: With hydrogenchloride in methanol; water pH=3 - 4;
参考文献
Organic and Biomolecular Chemistry, , vol. 11, # 22 p. 3635 - 3641
反应条件
1: With (R)-1-phenyl-ethyl-amine in ethanol; chloroform 0.75 h; Reflux; 2: With hydrogenchloride in ethanol; chloroform; water 0.75 h; Cooling;
参考文献
Arkivoc, , vol. 2010, # 10 p. 266 - 275
反应条件
1: With quinidine T=-50°C; 17 h; 2: With ammonia in water T=20 - 40°C; 72 h; 3: With hydrogenchloride in water pH=3; Product distribution / selectivity;
参考文献
US2007/293694 A1, ;
Page/Page column 11 ;
