3-(氨甲酰甲基)-5-甲基己酸合成路线 （共 16 条）
反应条件
1: With (R)-1-phenyl-ethyl-amine in ethanol; chloroform 0.75 h; Reflux; 2: With hydrogenchloride in ethanol; chloroform; water 0.75 h; Cooling;
参考文献
Arkivoc, , vol. 2010, # 10 p. 266 - 275
反应条件
(R)-1-phenyl-ethyl-amine Resolution of racemate;
参考文献
Organic Process Research and Development, , vol. 13, # 4 p. 812 - 814
反应条件
1: With sodium hydroxide; water; bromine T=5 - 60°C; Hofmann Rearrangement; 0.5 h; 2: With sulfuric acid in 2-methyl-propan-1-ol; water 3: With tributyl-amine in 2-methyl-propan-1-ol T=2 - 10°C; 1.5 - 2 h; Product distribution / selectivity;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.
Patent: WO2006/121557 A1, 2006 ;
Location in patent: Page/Page column 13-14; 17 ;
反应条件
1: With sodium hydroxide; water; bromine T=5 - 60°C; Hofmann Rearrangement; 0.5 h; 2: With sulfuric acid in 2-methyl-propan-1-ol; water 3: With tributyl-amine in 2-methyl-propan-1-ol T=2 - 10°C; 1.5 - 2 h; Product distribution / selectivity;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.
Patent: WO2006/121557 A1, 2006 ;
Location in patent: Page/Page column 13-14; 17 ;
反应条件
in ethanol; chloroform
T=30 - 55°C; 1 h; Product distribution / selectivity;
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.
Patent: WO2008/137512 A2, 2008 ;
Location in patent: Page/Page column 11 ;
反应条件
1: With sodium hydroxide; water; bromine
T=5 - 60°C; Hofmann Rearrangement; 0.5 h;
2: With sulfuric acid in 2-methyl-propan-1-ol; water
3: With tributyl-amine in 2-methyl-propan-1-ol
T=2 - 10°C; 1.5 - 2 h; Product distribution / selectivity;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.
Patent: WO2006/121557 A1, 2006 ;
Location in patent: Page/Page column 13-14; 17 ;
