3-(氨甲酰甲基)-5-甲基己酸合成路线 （共 16 条）
反应条件
1: With ammonia in tert-butyl methyl ether; water T=0 - 20°C; 2: With hydrogenchloride in tert-butyl methyl ether; water pH=2;
参考文献
WO2012/93411 A2, ;
Page/Page column 18-19 ;
反应条件
1: With chloroformic acid ethyl ester; triethylamine in acetone T=-20°C; Inert atmosphere; 2: With ammonia in water; acetone T=-20°C; 2 h; 3: With sodium hydroxide in water T=0°C;
参考文献
WO2012/93411 A2, ;
Page/Page column 20-21 ;
反应条件
ammonium hydroxide in water
反应条件
hydrogenchloride; ammonium hydroxide; acetic anhydride in tert-butyl methyl ether; water; ethyl acetate
反应条件
1: With toluene-4-sulfonic acid in toluene Reflux; 2: With sodium hydroxide in water; toluene T=25 - 65°C; 3: With hydrogenchloride in water T=10 - 15°C; 1.5 h; Product distribution / selectivity;
参考文献
WO2011/77463 A1, ;
Page/Page column 21 ;
反应条件
1.1: n-dipropylamine / 16 h / 15 - 55 °C 2.1: hydrogen bromide / water / 72 h / 100 °C 3.1: acetyl chloride / 3.08 h / 20 - 55 °C / Inert atmosphere 4.1: ammonia / water; tert-butyl methyl ether / 0 - 20 °C 4.2: pH 2 View Scheme
反应条件
1.1: hydrogen bromide / water / 72 h / 100 °C 2.1: acetyl chloride / 3.08 h / 20 - 55 °C / Inert atmosphere 3.1: ammonia / water; tert-butyl methyl ether / 0 - 20 °C 3.2: pH 2 View Scheme
反应条件
1: With (S)-1-phenyl-ethylamine in ethanol; chloroform 0.75 h; Reflux; 2: With hydrogenchloride in ethanol; chloroform; water 0.75 h; Cooling;
参考文献
Sripathi, Somaiah; Somesetti, Narender Rao; Veeramalla, Raju; Challa, Nageswar Rao; Peddi, Srinivasa Rao; Karnati, Venugopal Reddy
Arkivoc, 2010 , vol. 2010, # 10 p. 266 - 275
反应条件
(R)-1-phenyl-ethyl-amine Resolution of racemate;
参考文献
Chavan, Anil B.; Maikap, Golak C.; Gurjar, Mukund K.
Organic Process Research and Development, 2009 , vol. 13, # 4 p. 812 - 814
反应条件
1: With sodium hydroxide; water; bromine T=10 - 60°C; Hofmann Rearrangement; 0.5 - 5.75 h; 2: With sulfuric acid in 2-methyl-propan-1-ol; water T=20°C; 0.5 - 24 h; 3: With tributyl-amine in 2-methyl-propan-1-ol T=2°C; 1.5 - 2 h; Product distribution / selectivity;
参考文献
WO2006/121557 A1, ;
Page/Page column 14-16 ;
