3-(2,4-二甲基苯基)丙酸合成路线 （共 27 条）
反应条件
1: With hydrogen in ethanol T=20°C; 2: With water; sodium hydroxide in tetrahydrofuran; methanol T=20°C; 3: With hydrogenchloride in water
参考文献
DAIICHI SANKYO COMPANY, LIMITED
Patent: US2011/53974 A1, 2011 ;
Location in patent: Page/Page column 78 ;
反应条件
hydrogen; palladium on activated charcoal in 1,4-dioxane P=517.1 - 1551.4 Torr;
参考文献
Neudeck
Monatshefte fur Chemie, 1996 , vol. 127, # 2 p. 185 - 200
参考文献
Boyce, Rustum; Chu, Daniel
Patent: US2005/124652 A1, 2005 ;
US 20050124652 A1
反应条件
carbon monoxide; palladium on activated charcoal; 1,4-di(diphenylphosphino)-butane in ethylene glycol dimethyl ether T=150°C; P=5168 Torr; 24 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 58, # 17 p. 4739 - 4741
反应条件
carbon monoxide; palladium on activated charcoal; 1,4-di(diphenylphosphino)-butane in ethylene glycol dimethyl ether T=150°C; P=30400 Torr; 24 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 58, # 17 p. 4739 - 4741
反应条件
1.1: NaH / dimethylformamide / 0 - 20 °C 1.2: dimethylformamide / 20 °C 2.1: H2 / Pd/C / methanol 3.1: aq. NaOH / Heating View Scheme
参考文献
Molecules, , vol. 9, # 6 p. 449 - 458
反应条件
1: 95 percent / Friedel-Crafts alkylation 2: 88 percent / haloform reaction 3: 98.5 percent / conc. H2SO4 / 50 h / Heating 4: 96.2 percent / LiAlH4 / diethyl ether / 1.) reflux, 3 h, 2.) room temp., overnight 5: 89.6 percent / PCC / CH2Cl2 / 2 h / Ambient temperature 6: 95.2 percent / pyridine, piperidine / 48 h / 80 °C 7: 97 percent / H2 / 10percent Pd/C / dioxane / 517.1 - 1551.4 Torr View Scheme
参考文献
Monatshefte fur Chemie, , vol. 127, # 2 p. 185 - 200
反应条件
1: aluminium chloride 2: methanolic KOH-solution View Scheme
参考文献
Journal of the Chemical Society, , p. 2368
Journal of the Chemical Society, , p. 1110
反应条件
1: H2 / Pd/C / methanol 2: aq. NaOH / Heating View Scheme
参考文献
Molecules, , vol. 9, # 6 p. 449 - 458
反应条件
1: 89.6 percent / PCC / CH2Cl2 / 2 h / Ambient temperature 2: 95.2 percent / pyridine, piperidine / 48 h / 80 °C 3: 97 percent / H2 / 10percent Pd/C / dioxane / 517.1 - 1551.4 Torr View Scheme
参考文献
Monatshefte fur Chemie, , vol. 127, # 2 p. 185 - 200
