hydrogenchloride in methanol 1 h; Ambient temperature;

1: 92 percent / SOCl2 / CH2Cl2 / 1.) room temp., overnight, 2.) reflux, 2 h 2: 58 percent / Cs2CO3 / dimethylformamide / 24 h / 85 °C 3: 96 percent / HCl / methanol / 1 h / Ambient temperature View Scheme

1: 77 percent / 10percent aq. NaOH / CH2Cl2 / 4 h 2: 80 percent / dimethylformamide / 48 h / Ambient temperature 3: 74 percent / NaOMe / methanol / 0.08 h 4: 58 percent / Cs2CO3 / dimethylformamide / 24 h / 85 °C 5: 96 percent / HCl / methanol / 1 h / Ambient temperature View Scheme

1: 80 percent / SOCl2 / CH2Cl2 / 1.) room temp., overnight, 2.) reflux, 2 h 2: 77 percent / 10percent aq. NaOH / CH2Cl2 / 4 h 3: 80 percent / dimethylformamide / 48 h / Ambient temperature 4: 74 percent / NaOMe / methanol / 0.08 h 5: 58 percent / Cs2CO3 / dimethylformamide / 24 h / 85 °C 6: 96 percent / HCl / methanol / 1 h / Ambient temperature View Scheme

1: 58 percent / Cs2CO3 / dimethylformamide / 24 h / 85 °C 2: 96 percent / HCl / methanol / 1 h / Ambient temperature View Scheme

1: 95 percent / Na2CO3 / dimethylformamide / 96 h / Heating 2: 92 percent / SOCl2 / CH2Cl2 / 1.) room temp., overnight, 2.) reflux, 2 h 3: 58 percent / Cs2CO3 / dimethylformamide / 24 h / 85 °C 4: 96 percent / HCl / methanol / 1 h / Ambient temperature View Scheme