boron trifluoride diethyl etherate in diethyl ether 3 h; Ambient temperature;

1: 85 percent / 18-crown-6 ether / acetonitrile / 288 h / Ambient temperature 2: 2.) hydrochloric acid / !:) ethyl ether, THF, reflux, 2.5 h, 2.) reflux, 3 h 3: 69 percent / ethanol / 2 h / Heating 4: 21 percent / tert-butyllithium / pentane; tetrahydrofuran / 1.) -78 deg C, 24 h, 2.) room temperature 5: 85 percent / m-chloroperbenzoic acid / CHCl3 / 24 h / 0 °C 6: 93 percent / boron trifluoride etherate / diethyl ether / 3 h / Ambient temperature View Scheme

1: 40 percent / N-bromosuccinimide, benzoyl peroxide / CCl4 / 4.5 h / Heating 2: 85 percent / 18-crown-6 ether / acetonitrile / 288 h / Ambient temperature 3: 2.) hydrochloric acid / !:) ethyl ether, THF, reflux, 2.5 h, 2.) reflux, 3 h 4: 69 percent / ethanol / 2 h / Heating 5: 21 percent / tert-butyllithium / pentane; tetrahydrofuran / 1.) -78 deg C, 24 h, 2.) room temperature 6: 85 percent / m-chloroperbenzoic acid / CHCl3 / 24 h / 0 °C 7: 93 percent / boron trifluoride etherate / diethyl ether / 3 h / Ambient temperature View Scheme

1: 25 mg / tetrahydrofuran / 0.17 h / -78 °C 2: 40 percent / N-bromosuccinimide, benzoyl peroxide / CCl4 / 4.5 h / Heating 3: 85 percent / 18-crown-6 ether / acetonitrile / 288 h / Ambient temperature 4: 2.) hydrochloric acid / !:) ethyl ether, THF, reflux, 2.5 h, 2.) reflux, 3 h 5: 69 percent / ethanol / 2 h / Heating 6: 21 percent / tert-butyllithium / pentane; tetrahydrofuran / 1.) -78 deg C, 24 h, 2.) room temperature 7: 85 percent / m-chloroperbenzoic acid / CHCl3 / 24 h / 0 °C 8: 93 percent / boron trifluoride etherate / diethyl ether / 3 h / Ambient temperature View Scheme

1: 15 percent / tetrahydrofuran / 48 h / Heating 2: 40 percent / N-bromosuccinimide, benzoyl peroxide / CCl4 / 4.5 h / Heating 3: 85 percent / 18-crown-6 ether / acetonitrile / 288 h / Ambient temperature 4: 2.) hydrochloric acid / !:) ethyl ether, THF, reflux, 2.5 h, 2.) reflux, 3 h 5: 69 percent / ethanol / 2 h / Heating 6: 21 percent / tert-butyllithium / pentane; tetrahydrofuran / 1.) -78 deg C, 24 h, 2.) room temperature 7: 85 percent / m-chloroperbenzoic acid / CHCl3 / 24 h / 0 °C 8: 93 percent / boron trifluoride etherate / diethyl ether / 3 h / Ambient temperature View Scheme

1: 85 percent / m-chloroperbenzoic acid / CHCl3 / 24 h / 0 °C 2: 93 percent / boron trifluoride etherate / diethyl ether / 3 h / Ambient temperature View Scheme

1: 69 percent / ethanol / 2 h / Heating 2: 21 percent / tert-butyllithium / pentane; tetrahydrofuran / 1.) -78 deg C, 24 h, 2.) room temperature 3: 85 percent / m-chloroperbenzoic acid / CHCl3 / 24 h / 0 °C 4: 93 percent / boron trifluoride etherate / diethyl ether / 3 h / Ambient temperature View Scheme

1: 2.) hydrochloric acid / !:) ethyl ether, THF, reflux, 2.5 h, 2.) reflux, 3 h 2: 69 percent / ethanol / 2 h / Heating 3: 21 percent / tert-butyllithium / pentane; tetrahydrofuran / 1.) -78 deg C, 24 h, 2.) room temperature 4: 85 percent / m-chloroperbenzoic acid / CHCl3 / 24 h / 0 °C 5: 93 percent / boron trifluoride etherate / diethyl ether / 3 h / Ambient temperature View Scheme

1: 21 percent / tert-butyllithium / pentane; tetrahydrofuran / 1.) -78 deg C, 24 h, 2.) room temperature 2: 85 percent / m-chloroperbenzoic acid / CHCl3 / 24 h / 0 °C 3: 93 percent / boron trifluoride etherate / diethyl ether / 3 h / Ambient temperature View Scheme

1: 1.) tert-butyllithium / 1.) pentane, 2.) reflux 2: 85 percent / m-chloroperbenzoic acid / CHCl3 / 24 h / 0 °C 3: 93 percent / boron trifluoride etherate / diethyl ether / 3 h / Ambient temperature View Scheme