2-氯-3,4-二甲氧基苯甲醛合成路线 （共 15 条）
反应条件
sodium tetrahydroborate in dichloromethane
T=20°C; 0.5 h;
参考文献
Feng, Lianshun; Lv, Kai; Liu, Mingliang; Wang, Shuo; Zhao, Jing; You, Xuefu; Li, Sujie; Cao, Jue; Guo, Huiyuan
European Journal of Medicinal Chemistry, 2012 , vol. 55, p. 125 - 136
反应条件
1: With AlCl3, aluminium chloride in dichloromethane
T=20°C;
2: With water in dichloromethane
参考文献
PLEXXIKON, INC.
Patent: WO2008/80001 A2, 2008 ;
Location in patent: Page/Page column 92-93 ;
反应条件
1: 75 percent / ethanol / 2 h / Heating
2: 85 percent / NaBH4 / ethanol / 3 h / Heating
3: KNH2, NH3 (liq.) / diethyl ether / 3 h
4: MnO2 / CHCl3
View Scheme
参考文献
Kessar, Satinder V.; Gupta, Yash P.; Balakrishnan, Prasanna; Sawal, Kewal K.; Mohammad, Taj; Dutt, Mahesh
Journal of Organic Chemistry, 1988 , vol. 53, # 8 p. 1708 - 1713
反应条件
1: sodium tetrahydroborate / dichloromethane / 0.5 h / 20 °C
2: phosphorus tribromide / dichloromethane / 0.5 h / 0 °C
View Scheme
参考文献
Feng, Lianshun; Lv, Kai; Liu, Mingliang; Wang, Shuo; Zhao, Jing; You, Xuefu; Li, Sujie; Cao, Jue; Guo, Huiyuan
European Journal of Medicinal Chemistry, 2012 , vol. 55, p. 125 - 136
反应条件
hydrogen bromide; acetic acid
参考文献
Squier; Van der Schyf; Oliver; Venter
Arzneimittel-Forschung/Drug Research, 1986 , vol. 36, # 3 p. 457 - 460
