3-(((叔丁氧基羰基)氨基)甲基)苯甲酸甲酯合成路线 （共 13 条）
反应条件
sodium hydrogencarbonate in dichloromethane; water 2 h;
参考文献
Khilevich, Albert; Liu, Bin; Mayhugh, Daniel Ray; Schkeryantz, Jeffrey Michael; Zhang, Deyi
Patent: US2010/16373 A1, 2010 ;
Location in patent: Page/Page column 16 ;
反应条件
hydrogen; palladium 10 on activated carbon in ethyl acetate P=3800.26 Torr;
参考文献
Evotec OAI AG; DeveloGen Aktiengesellschaft
Patent: EP1655283 A1, 2006 ;
Location in patent: Page/Page column 11; 15 ;
反应条件
dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; potassium carbonate in water; toluene T=85°C; Suzuki-Miyaura cross-coupling reaction; 22 h; Inert atmosphere;
参考文献
Molander, Gary A.; Shin, Inji
Organic Letters, 2011 , vol. 13, # 15 p. 3956 - 3959
反应条件
triethylamine in dichloromethane
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1577302 A1, 2005 ;
Location in patent: Page/Page column 116-117 ;
反应条件
1: N-bromosuccinmide / 2,2'-azo-bisisobutyronitrile / tetrachloromethane / 3 h / 25 °C / Reflux 2: thionyl chloride / 1 h / 25 °C / Reflux 3: N,N-dimethyl-formamide / 12 h / 85 °C 4: hydrazine hydrate / methanol / 4 h / 25 °C / Reflux 5: sodium hydrogencarbonate / ethyl acetate; water / 1.17 h / pH 8 View Scheme
参考文献
ANTHEM BIOSCIENCES PRIVATE LIMITED
Patent: US2012/101099 A1, 2012 ;
反应条件
1.1: potassium hexamethylsilazane / tetrahydrofuran / 2.25 h / -78 - 20 °C 1.2: 1 h / 0 °C 1.3: 0 - 20 °C 2.1: KHF2 / methanol; water / 0 - 20 °C 3.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; potassium carbonate / water; toluene / 22 h / 85 °C / Inert atmosphere View Scheme
参考文献
Molander, Gary A.; Shin, Inji
Organic Letters, 2011 , vol. 13, # 15 p. 3956 - 3959
反应条件
1: thionyl chloride / 1 h / 25 °C / Reflux 2: N,N-dimethyl-formamide / 12 h / 85 °C 3: hydrazine hydrate / methanol / 4 h / 25 °C / Reflux 4: sodium hydrogencarbonate / ethyl acetate; water / 1.17 h / pH 8 View Scheme
参考文献
ANTHEM BIOSCIENCES PRIVATE LIMITED
Patent: US2012/101099 A1, 2012 ;
反应条件
1: N,N-dimethyl-formamide / 12 h / 85 °C 2: hydrazine hydrate / methanol / 4 h / 25 °C / Reflux 3: sodium hydrogencarbonate / ethyl acetate; water / 1.17 h / pH 8 View Scheme
参考文献
ANTHEM BIOSCIENCES PRIVATE LIMITED
Patent: US2012/101099 A1, 2012 ;
反应条件
1: hydrazine hydrate / methanol / 4 h / 25 °C / Reflux 2: sodium hydrogencarbonate / ethyl acetate; water / 1.17 h / pH 8 View Scheme
参考文献
ANTHEM BIOSCIENCES PRIVATE LIMITED
Patent: US2012/101099 A1, 2012 ;
反应条件
hydrogenchloride in 1,4-dioxane; dichloromethane T=20°C; 4.5 h;
参考文献
Evotec OAI AG; DeveloGen Aktiengesellschaft
Patent: EP1655283 A1, 2006 ;
Location in patent: Page/Page column 16 ;
