4,4-亚甲基双(n-甲基苯胺)合成路线 （共 29 条）
参考文献
v. Braun
Chemische Berichte, 1908 , vol. 41, p. 2117
Chemische Berichte, 1909 , vol. 42, p. 2056
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran
24 h; Inert atmosphereReflux;
2: With Glauber's salt in tetrahydrofuran
1 h; Inert atmosphereReflux;
参考文献
Kimura, Tsutomu; Hosokawa-Muto, Junji; Kamatari, Yuji O.; Kuwata, Kazuo
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 5 p. 1502 - 1507
反应条件
hydrogenchloride in water
T=90 - 95°C; 1 h;
参考文献
Sharma, Lalit
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2002 , vol. 41, # 7 p. 1504 - 1506
反应条件
zinc(II) chloride in ethanol
T=60°C; Mannich reaction; 24 h;
参考文献
Chen, Lei; Hu, Tai-Shan; Zhu, Jing; Wu, Houming; Yao, Zhu-Jun
Synlett, 2006 , # 8 p. 1225 - 1229
反应条件
in diethyl ether
T=0 - 25°C; 0.416667 h;
参考文献
Barbero, Margherita; Degani, Iacopo; Dughera, Stefano; Fochi, Rita
Synthesis, 2003 , # 5 p. 742 - 750
反应条件
in tetrahydrofuran
T=20°C; 36 h;
参考文献
Barluenga, Jose; Campos, Pedro J.; Roy, Miguel A.; Asensio, Gregorio
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1420 - 1426
反应条件
1.1: isopentyl nitrite; HCO2H / 0 - 5 °C
2.1: NaOMe / methanol
2.2: 91 percent / methanol / 0.5 h / 20 - 25 °C
3.1: 82 percent / diethyl ether / 0.42 h / 0 - 25 °C
View Scheme
参考文献
Barbero, Margherita; Degani, Iacopo; Dughera, Stefano; Fochi, Rita
Synthesis, 2003 , # 5 p. 742 - 750
反应条件
in ethanol; water
T=20°C; 20 h;
参考文献
Rivera, Augusto; Torres, Olga Lucia; Leiton, Jesus D.; Morales-Rios, Martha S.; Joseph-Nathan, Pedro
Synthetic Communications, 2002 , vol. 32, # 9 p. 1407 - 1414
参考文献
Barluenga, Jose; Campos, Pedro J.; Roy, Miguel A.; Asensio, Gregorio
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1420 - 1426
反应条件
hydrogenchloride
7 h; Heating;
参考文献
Katritzky, Alan R.; El-Zemity, Saad; Lang, Hengyuan
Heterocycles, 1994 , vol. 38, # 8 p. 1813 - 1822
