17,21-二羟基孕甾-4-烯-3,20-二酮17,21-二(乙酸酯)合成路线 （共 12 条）
反应条件
potassium acetate; acetic acid in N,N-dimethyl-formamide; toluene
参考文献
The Upjohn Company
Patent: US4500461 A1, 1985 ;
反应条件
toluene-4-sulfonic acid; acetic acid
参考文献
Turner
Journal of the American Chemical Society, 1953 , vol. 75, p. 3484
反应条件
toluene-4-sulfonic acid in acetic acid
参考文献
Ferraboschi, Patrizia; Mieri, Maria De; Ragonesi, Laura
Tetrahedron Letters, 2008 , vol. 49, # 31 p. 4610 - 4612
反应条件
1: 0.015 g / diacetoxyiodobenzene, iodine / acetic acid / 0.17 h / 25 °C 2: 0.008 g / Et3N, acetic acid / acetone / 24 h / 20 - 25 °C 3: 0.003 g / N-methylpyrrolidone / 24 h / 20 - 25 °C View Scheme
参考文献
Turuta, A. M.; Vesela, I. V.; Kamernitskii, A. V.; Vlakhov, Rodoslav
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1991 , vol. 40, # 12 p. 2508 - 2511
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1991 , vol. 40, # 12 p. 2875 - 2878
反应条件
1: 0.008 g / Et3N, acetic acid / acetone / 24 h / 20 - 25 °C 2: 0.003 g / N-methylpyrrolidone / 24 h / 20 - 25 °C View Scheme
参考文献
Turuta, A. M.; Vesela, I. V.; Kamernitskii, A. V.; Vlakhov, Rodoslav
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1991 , vol. 40, # 12 p. 2508 - 2511
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1991 , vol. 40, # 12 p. 2875 - 2878
反应条件
1: 7.46 g / p-toluenesulfonic acid / benzene / 7 h / Heating 3: 1.) 30percent HClO4, 2.) aq. ammonia / 1.) CH2Cl2, -5 to -4 deg C, 20 min, 2.) pH 7, 2 h View Scheme
参考文献
Ryakhovskaya, M. I.; Popova, E. V.; Andryushina, V. A.; Grinenko, G. S.
Pharmaceutical Chemistry Journal, 1990 , vol. 24, # 11 p. 839 - 842
Khimiko-Farmatsevticheskii Zhurnal, 1990 , vol. 24, # 11 p. 55 - 57
反应条件
1-methyl-pyrrolidin-2-one T=20 - 25°C; 24 h;
参考文献
Turuta, A. M.; Vesela, I. V.; Kamernitskii, A. V.; Vlakhov, Rodoslav
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1991 , vol. 40, # 12 p. 2508 - 2511
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1991 , vol. 40, # 12 p. 2875 - 2878
反应条件
2: 1.) 30percent HClO4, 2.) aq. ammonia / 1.) CH2Cl2, -5 to -4 deg C, 20 min, 2.) pH 7, 2 h View Scheme
参考文献
Ryakhovskaya, M. I.; Popova, E. V.; Andryushina, V. A.; Grinenko, G. S.
Pharmaceutical Chemistry Journal, 1990 , vol. 24, # 11 p. 839 - 842
Khimiko-Farmatsevticheskii Zhurnal, 1990 , vol. 24, # 11 p. 55 - 57
反应条件
ammonium hydroxide; perchloric acid 1.) CH2Cl2, -5 to -4 deg C, 20 min, 2.) pH 7, 2 h; Multistep reaction. Yields of byproduct given;
参考文献
Ryakhovskaya, M. I.; Popova, E. V.; Andryushina, V. A.; Grinenko, G. S.
Pharmaceutical Chemistry Journal, 1990 , vol. 24, # 11 p. 839 - 842
Khimiko-Farmatsevticheskii Zhurnal, 1990 , vol. 24, # 11 p. 55 - 57
参考文献
Nedelec, Lucien; Torelli, Vesperto; Hardy, Michel
Journal of the Chemical Society, Chemical Communications, 1981 , # 15 p. 775 - 777
