6-甲基麦角灵-8β-甲醇合成路线 （共 11 条）
反应条件
hydrogen; palladium on activated carbon in N,N-dimethyl-formamide T=50 - 60°C; P=2068.65 - 2585.81 Torr;
参考文献
Apotex Pharmachem Inc.
Patent: US2008/275240 A1, 2008 ;
Location in patent: Page/Page column 9 ;
反应条件
sodium tetrahydroborate in methanol 2 h; Heating;
参考文献
Ohno; Adachi; Koumori; Mizukoshi; Nagasaka; Ichihara; Kato -
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 7 p. 1463 - 1473
反应条件
methanol; nickel in 1,4-dioxane Heating;
参考文献
Mayer; Eich
Pharmazie, 1984 , vol. 39, # 8 p. 537 - 538
反应条件
1: H2SO4 2: 82 percent / aq. NaBH4 / methanol / 2 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 42, # 7 p. 1463 - 1473
反应条件
1: platinum; acetic acid / Hydrogenation 2: HCl 3: sodium; butan-1-ol View Scheme
参考文献
Journal of Biological Chemistry, , vol. 115, p. 227,237
参考文献
Helvetica Chimica Acta, , vol. 38, p. 1964,1968, 1969, 1974
反应条件
1: 80 percent / pyridine / 3 h / Ambient temperature 2: 1.) NaH / 1.) DMF, 2.) DMF, 90 deg C, 2 h View Scheme
参考文献
Ohno; Adachi; Koumori; Mizukoshi; Nagasaka; Ichihara; Kato -
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 7 p. 1463 - 1473
反应条件
1: pyridine / 0 °C 2: dimethylsulfoxide / 50 °C View Scheme
参考文献
Mantegani, Sergio; Brambilla, Enzo; Caccia, Carla; Chiodini, Laura; Ruggieri, Daniela; Lamberti, Ernesto; Di Salle, Enrico; Salvati, Patricia
Farmaco, 1998 , vol. 53, # 4 p. 293 - 304
反应条件
1: K3PO4*3H2O / tetrahydrothiophene 1,1-dioxide / 2 h / 110 °C 2: 241 mg / Na2S*9H2O / tetrahydrothiophene 1,1-dioxide / 5 h / 120 °C 3: pyridine / 1 h / 0 °C 4: 6.53 percent / dimethylformamide / 2 h / 20 °C View Scheme
参考文献
Anastasia; Cighetti; Allevi
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 19 p. 2398 - 2403
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran Ambient temperature;
参考文献
Mantegani, Sergio; Brambilla, Enzo; Caccia, Carla; Damiani, Gabriele; Fornaretto, Maria Gioia; McArthur, Robert A.; Varasi, Mario
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 9 p. 1117 - 1122
