1,4-二甲基-9H-咔唑合成路线 （共 61 条）
反应条件
1: 1,4-dimethyl-9H-carbazole; N,N-dimethyl-formamide With trichlorophosphate in chlorobenzene T=131°C; 6.5 h; 2: 2,2-diethoxy-ethanamine T=110°C; 4 h;
参考文献
Deane, Fiona M.; Miller, Charlotte M.; Maguire, Anita R.; McCarthy, Florence O.
Journal of Heterocyclic Chemistry, 2011 , vol. 48, # 4 p. 814 - 823
反应条件
1: 1,4-dimethyl-9H-carbazole With sodium hydride in N,N-dimethyl-formamide; mineral oil T=0°C; 0.25 h; Inert atmosphere; 2: methyl iodide in N,N-dimethyl-formamide; mineral oil T=0 - 20°C; Inert atmosphere;
参考文献
Deane, Fiona M.; O'Sullivan, Elaine C.; Maguire, Anita R.; Gilbert, Jayne; Sakoff, Jennette A.; McCluskey, Adam; McCarthy, Florence O.
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 8 p. 1334 - 1344
反应条件
ammonia; sodium amide und Behandeln der Reaktionsloesung mit Methyljodid;
参考文献
Robinson; Saxton
Journal of the Chemical Society, 1953 , p. 2596,2599
反应条件
1: 46 percent / POCl3 / various solvent(s) / 5 h / Heating 2: 82.7 percent / 2 h / 100 °C 3: 74.6 percent / H2 / Raney nickel / ethanol / 6080 Torr / Ambient temperature 4: 92 percent / pyridine / 72 h / Ambient temperature 5: 80 percent / 6 M hydrochloric acid / dioxane / 6.5 h / Heating View Scheme
参考文献
Mustafin; Khalilov; Ismagilov; Baimetov; Spirikhin; Abdrakhmanov; Tolstikov
Russian Chemical Bulletin, 1999 , vol. 48, # 11 p. 2121 - 2126
反应条件
nitric acid; acetic anhydride 3 h; Ambient temperature;
参考文献
Letois, B; Lancelot, J C; Rault, S; Robba, M; Tabka, T; et al.
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 9 p. 775 - 784
反应条件
nitric acid; acetic anhydride 3 h; Ambient temperature;
参考文献
European Journal of Medicinal Chemistry, , vol. 25, # 9 p. 775 - 784
反应条件
1: 20 percent / AlCl3 / toluene / 3 h / Heating 2: 59 percent / HNO3, acetic anhydride / 3 h / 20 °C View Scheme
参考文献
Lancelot, Jean-Charles; Letois, Bertrand; Rault, Sylvain; Dung, Nguyen Huy; Saturnino, Carmela; Robba, Max
Gazzetta Chimica Italiana, 1991 , vol. 121, # 6 p. 301 - 307
反应条件
trichlorophosphate in 1,2-dichloro-benzene T=70°C; Vilsmeier-Haack formylation;
参考文献
Lee, Hsueh-Yun; Chen, Grace Shiahuy; Chen, Chien-Shu; Cherna, Ji-Wang
Journal of Heterocyclic Chemistry, 2010 , vol. 47, # 2 p. 454 - 458
反应条件
trichlorophosphate in 1,1,2-trichloroethylene T=87.5°C; 3.5 h;
参考文献
Deane, Fiona M.; Miller, Charlotte M.; Maguire, Anita R.; McCarthy, Florence O.
Journal of Heterocyclic Chemistry, 2011 , vol. 48, # 4 p. 814 - 823
反应条件
trichlorophosphate in chlorobenzene Vilsmeier-Haack Formylation; 6.5 h; Reflux;
参考文献
Deane, Fiona M.; O'Sullivan, Elaine C.; Maguire, Anita R.; Gilbert, Jayne; Sakoff, Jennette A.; McCluskey, Adam; McCarthy, Florence O.
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 8 p. 1334 - 1344
