1: methanecarbohydroxamic acid With potassium tert-butylate in N,N-dimethyl-formamide T=30°C; 2: 3-cyano-4-fluoro-bromobenzene in N,N-dimethyl-formamide 3: With potassium tert-butylate in N,N-dimethyl-formamide
1: α-cyanoacetic acid methyl ester With sodium hydride in dimethyl sulfoxide T=20°C; 0.5 h; 2: 3-cyano-4-fluoro-bromobenzene in dimethyl sulfoxide T=90°C; 3: With water in dimethyl sulfoxide Heating; Further stages.;
参考文献
Frohn, Mike; Buerli, Roland W.; Riahi, Bobby; Hungate, Randall W.
Tetrahedron Letters, 2007 , vol. 48, # 3 p. 487 - 489
1: With n-butyllithium; tri-isopropoxy-borane in tetrahydrofuran; hexane; toluene T=-70°C; 1 h; 2: With hydrogenchloride; water in tetrahydrofuran; hexane; toluene T=-20 - 20°C;
参考文献
MERCK PATENT GMBH
Patent: WO2006/45350 A1, 2006 ;
Location in patent: Page/Page column 62-63 ;
WO 2006/045350 A1
1: With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in dimethyl sulfoxide 2: With hydrogenchloride in tetrahydrofuran; water
参考文献
DuPont Pharmaceuticals Company
Patent: US6339099 B1, 2002 ;
Location in patent: Page column 83-86 ;
