2-氟-5-溴苯腈合成路线

202865-65-45-溴-2-氟苯甲醛肟

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179897-89-32-氟-5-溴苯腈

参考文献

Bioorganic and Medicinal Chemistry Letters, , vol. 19, # 1 p. 279 - 282

546-88-3乙酰氧肟酸+

179897-89-32-氟-5-溴苯腈

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455280-00-93-胺基-5-溴苯并[D]异噁唑

参考文献

WO2010/138488 A1, ;

Page/Page column 57-58 ;
WO 2010/138488 A1

179897-89-32-氟-5-溴苯腈

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455280-00-93-胺基-5-溴苯并[D]异噁唑

参考文献

WO2006/122799 A1, ;

Page/Page column 60-61 ;

179897-89-32-氟-5-溴苯腈+

105-34-0氰乙酸甲酯

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925672-89-54-溴-2-氰基苯乙腈

参考文献

Frohn, Mike; Buerli, Roland W.; Riahi, Bobby; Hungate, Randall W.
Tetrahedron Letters, 2007 , vol. 48, # 3 p. 487 - 489

179897-89-32-氟-5-溴苯腈

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214210-17-05-溴-2-氟苯甲酰胺

参考文献

AstraZeneca AB
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179897-89-32-氟-5-溴苯腈

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874784-09-55-(5-溴-2-氟苯基)-2H-四唑

参考文献

Journal of Medicinal Chemistry, , vol. 54, # 2 p. 572 - 579

5419-55-6硼酸三异丙酯+

179897-89-32-氟-5-溴苯腈

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214210-21-63-氰基-4-氟苯硼酸

参考文献

AstraZeneca AB
Patent: US6300352 B1, 2001 ;
US 6300352 B1

179897-89-32-氟-5-溴苯腈

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214210-21-63-氰基-4-氟苯硼酸

参考文献

MERCK PATENT GMBH
Patent: WO2006/45350 A1, 2006 ;
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WO 2006/045350 A1

179897-89-32-氟-5-溴苯腈+

73183-34-3联硼酸频那醇酯

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214210-21-63-氰基-4-氟苯硼酸

参考文献

DuPont Pharmaceuticals Company
Patent: US6339099 B1, 2002 ;
Location in patent: Page column 83-86 ;

920-39-8异丙基溴化镁+

179897-89-32-氟-5-溴苯腈

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218301-22-52-氟-5-甲酰基苯腈

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PFIZER LIMITED; PFIZER INC.
Patent: WO2004/20414 A1, 2004 ;
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WO 2004/020414 A1