1-(4-氯苯基)-3-二甲氨基-1-丙酮盐酸盐合成路线 （共 13 条）
反应条件
1: With hydrogenchloride in ethanol; water 5 h; Reflux; 2: With sodium hydrogencarbonate in dichloromethane; water 0.333333 h; 3: With hydrogenchloride in ethyl acetate
参考文献
Shanghai Institute of Pharmaceutical Industry; Li, Jianqi; Zheng, Yongyong; Liao, Yunfeng; Li, Yali
Patent: US2013/72488 A1, 2013 ;
Location in patent: Paragraph 0169 ;
反应条件
in acetonitrile 2 h; Ambient temperature;
参考文献
Dimmock; Shyam; Hamon; Logan; Raghavan; Harwood; Smith
Journal of Pharmaceutical Sciences, 1983 , vol. 72, # 8 p. 887 - 894
反应条件
hydrogenchloride in ethanol T=60°C; Mannich reaction;
参考文献
Heterocyclic Communications, , vol. 11, # 2 p. 135 - 138
反应条件
in ethanol; water 16 h; Heating;
参考文献
Ogata, Masaru; Matsumoto, Hiroshi; Kida, Shiro; Shimizu, Sumio; Tawara, Katsuya; Kawamura, Yoshimi
Journal of Medicinal Chemistry, 1987 , vol. 30, # 8 p. 1497 - 1502
反应条件
1: ethanol; H2O / 16 h / Heating 2: Ac2O / 1.5 h / 60 °C View Scheme
参考文献
Ogata, Masaru; Matsumoto, Hiroshi; Kida, Shiro; Shimizu, Sumio; Tawara, Katsuya; Kawamura, Yoshimi
Journal of Medicinal Chemistry, 1987 , vol. 30, # 8 p. 1497 - 1502
反应条件
1: ethanol; H2O / 16 h / Heating 2: Ac2O / 1.5 h / 60 °C View Scheme
参考文献
Ogata, Masaru; Matsumoto, Hiroshi; Kida, Shiro; Shimizu, Sumio; Tawara, Katsuya; Kawamura, Yoshimi
Journal of Medicinal Chemistry, 1987 , vol. 30, # 8 p. 1497 - 1502
反应条件
sodium tetrahydroborate in methanol; water 6 h;
参考文献
Avramova; Dryanovska; Ilarionov
Pharmazie, 1983 , vol. 38, # 7 p. 443 - 444
反应条件
(i) N2H4*H2O, aq. KOH, MeOH, (ii) (thermolysis); Multistep reaction;
参考文献
Applequist,D.E.; McKenzie,L.F.
Journal of Organic Chemistry, 1976 , vol. 41, p. 2262 - 2266
反应条件
in ethanol; water
16 h; Heating;
参考文献
Ogata, Masaru; Matsumoto, Hiroshi; Kida, Shiro; Shimizu, Sumio; Tawara, Katsuya; Kawamura, Yoshimi
Journal of Medicinal Chemistry, 1987 , vol. 30, # 8 p. 1497 - 1502
反应条件
hydrogen bromide; sodium carbonate
2) acetone, ether; Yield given. Multistep reaction;
参考文献
Dimmock; Shyam; Hamon; Logan; Raghavan; Harwood; Smith
Journal of Pharmaceutical Sciences, 1983 , vol. 72, # 8 p. 887 - 894
