3,4-吡啶二羧酸二甲酯合成路线 （共 18 条）
反应条件
4-(N,N-dimethlyamino)pyridine; thionyl chloride T=0°C; 48 h; Reflux;
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Jiancun; ZHANG, Yingjun; ZHANG, Weihong; LIU, Bing; ZHANG, Jiquan; LIU, Jinlei; ZHANG, Lu
Patent: WO2013/71697 A1, 2013 ;
Location in patent: Paragraph 00380 ;
反应条件
1: methanol; pyridine-3,4-dicarboxylic acid anhydride With 1,8-diazabicyclo[5.4.0]undec-7-ene T=20°C; 0.166667 h; 2: methyl iodide With 1,8-diazabicyclo[5.4.0]undec-7-ene in methanol T=20°C; chemoselective reaction;
参考文献
Jana, Amit Kumar; Karmakar, Raju; Dinda, Bidyut Kumar; Mitra, Prithiba; Ghosh, Ketaki; Karmakar, Rajdip; Mal, Dipakranjan
Journal of the Indian Chemical Society, 2012 , vol. 89, # 7 p. 975 - 979
反应条件
thionyl chloride in methanol 24 h; Heating;
参考文献
Hashimoto, Kimiko; Higashibayashi, Shuhei; Shirahama, Haruhisa
Heterocycles, 1997 , vol. 46, # 1 p. 581 - 588
参考文献
Jana, Amit Kumar; Karmakar, Raju; Dinda, Bidyut Kumar; Mitra, Prithiba; Ghosh, Ketaki; Karmakar, Rajdip; Mal, Dipakranjan
Journal of the Indian Chemical Society, 2012 , vol. 89, # 7 p. 975 - 979
参考文献
Kaas
Monatshefte fuer Chemie, 1902 , vol. 23, p. 252
反应条件
sodium hydroxide; water T=20°C; 1.5 h; Yields of byproduct given;
参考文献
Ashcroft, William R.; Beal, Michael G.; Joule, John A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 3012 - 3015
参考文献
Kaas
Monatshefte fuer Chemie, 1902 , vol. 23, p. 255,683
Full Text Show Details
Kirpal
Monatshefte fuer Chemie, 1902 , vol. 23, p. 932,936
反应条件
sodium hydroxide; water T=20°C; 1.5 h; Yields of byproduct given;
参考文献
Ashcroft, William R.; Beal, Michael G.; Joule, John A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 3012 - 3015
参考文献
Kirpal
Monatshefte fuer Chemie, 1902 , vol. 23, p. 932,936
反应条件
1: sodium hydroxide, water / 1.5 h / 20 °C 2: 5.1 g / lithium aluminium hydride / tetrahydrofuran / 0.07 h / 0 - 2 °C View Scheme
参考文献
Ashcroft, William R.; Beal, Michael G.; Joule, John A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 3012 - 3015
