N3-甲基-3,4-吡啶二胺合成路线 （共 9 条）
反应条件
hydrogen; nickel in methanol
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2005/44793 A2, 2005 ;
Location in patent: Page/Page column 239 ;
WO 2005/044793 A2
反应条件
palladium 10 on activated carbon; hydrogen in methanol; ethylene glycol dimethyl ether T=20°C; P=2068.65 Torr;
参考文献
Zhang, Lei; Rogers, Bruce N.; Duplantier, Allen J.; McHardy, Stanley F.; Efremov, Ivan; Berke, Helen; Qian, Weimin; Zhang, Andy Q.; Maklad, Noha; Candler, John; Doran, Angela C.; Lazzaro Jr., John T.; Ganong, Alan H.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 20 p. 5493 - 5496
反应条件
1: 65 percent / CHCl3 / 0.25 h / 0 °C 2: H2 / 5percent Pd/C / ethanol View Scheme
参考文献
Katner; Brown
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 3 p. 563 - 566
反应条件
1: HNO3 3: reducing agent <H> View Scheme
参考文献
Yano, Yumihiko; Yatsu, Isao; Oya, Eiichi; Ohshima, Masashi
Chemistry Letters, 1983 , p. 775 - 778
反应条件
2: reducing agent <H> View Scheme
参考文献
Yano, Yumihiko; Yatsu, Isao; Oya, Eiichi; Ohshima, Masashi
Chemistry Letters, 1983 , p. 775 - 778
参考文献
Cheil Foods and Chemicals, Inc.
Patent: US5281589 A1, 1994 ;
参考文献
Katner; Brown
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 3 p. 563 - 566
反应条件
boric acid in acetic acid
20 h; Ambient temperature;
参考文献
Yano, Yumihiko; Ohshima, Masashi; Yatsu, Isao; Sutoh, Susumu; Vasquez, Rafael E.; et al.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1985 , p. 753 - 758
参考文献
Katner; Brown
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 3 p. 563 - 566
