4-(5-(4-(戊基氧基)苯基)异噁唑-3-基)苯甲酸甲酯合成路线 （共 8 条）
反应条件
triethylamine in tetrahydrofuran
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 11 p. 3253 - 3256
反应条件
triethylamine in tetrahydrofuran T=40°C; 2.5 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 9 p. 2886 - 2890
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 65 - 70 °C 2: potassium tert-butylate / N,N-dimethyl-formamide / 4 h / 20 - 25 °C / |Large scale 3: hydroxylamine hydrochloride / 1-methyl-pyrrolidin-2-one / 30 h / 60 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 9, # 2 p. 179 - 184
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 65 - 70 °C 2: potassium tert-butylate / N,N-dimethyl-formamide / 4 h / 20 - 25 °C / |Large scale 3: hydroxylamine hydrochloride / 1-methyl-pyrrolidin-2-one / 30 h / 60 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 9, # 2 p. 179 - 184
反应条件
1: potassium tert-butylate / N,N-dimethyl-formamide / 4 h / 20 - 25 °C / |Large scale 2: hydroxylamine hydrochloride / 1-methyl-pyrrolidin-2-one / 30 h / 60 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 9, # 2 p. 179 - 184
反应条件
1: diethyl dicarbonate / tetrahydrofuran 2: tetrachloromethane / acetonitrile / |Reflux 3: trifluoroacetic acid 4: triethylamine / tetrahydrofuran View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 11 p. 3253 - 3256
反应条件
1: trifluoroacetic acid 2: triethylamine / tetrahydrofuran View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 11 p. 3253 - 3256
反应条件
1: 97.8 percent / NaOH / ethanol; tetrahydrofuran 2: 94.9 percent / CH2Cl2 View Scheme
参考文献
Ohigashi, Atsushi; Kanda, Atsushi; Tsuboi, Hiroyuki; Hashimoto, Norio
Organic Process Research and Development, 2005 , vol. 9, # 2 p. 179 - 184
